DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	529	Identity:	140/529 - (26%)
Similarity:	254/529 - (48%)	Gaps:	49/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHE-----ITSVSPFPSEEPVKN 66
            :::::....|....|:|:.:.|:...||.|    ..|.|||..||     :..:|......| .|
Mouse     7 YFMLLWSAVGIARAAKIIIVPPIMFESHLY----IFKTLASALHERGHHTVLLLSEGRDIAP-SN 66

  Fly    67 IYDIY-VPEVLNSFDELLKQMTTPKNTW-------EFFDATNEFVYNITKDVFNN---DGVRREI 120
            .|.:. .|.:.||........:..:|.:       |..|..:.:..|....|.|.   .|:::|
Mouse    67 HYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKE- 130

  Fly   121 LRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLA----PCGIDWKIDEMVGNPSPMSYLQSPS 181
                  :|||::||.      ..:..:..|.::|:.    ..|: |...| ||.|:|::|:...:
Mouse   131 ------KFDLLLVDP------NDMCGFVIAHLLGVKYAVFSTGL-WYPAE-VGAPAPLAYVPEFN 181

  Fly   182 SYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQ 246
            |.|.:...|..|:.:.....||.....:....|:|.:.:||  .:...|.:.::....:|.::..
Mouse   182 SLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKY--NLLPAKSMYDLVHGSSLWMLCT 244

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311
            ...|..|||.:|||:.|||: :.:....|.:||:.::.|:.|||.:..|.|..|  |.:.:|...
Mouse   245 DVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGV--KYLSEDIAN 306

  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            .|..|.|.|||:|:|:|...:.:::.:|..:.:||||.|||.|..::.|::|||:.|..|::::|
Mouse   307 KLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHG 371

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441
            .|::|:|.|.|.:..:..::..|..:.|.::.:|..||...:::::....:...|:.....::||
Mouse   372 VPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQ 436

  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506
            |..|:....:|..|:|||.||.|:|.|..::||..:..||:...:||..:|:...:..:..|...
Mouse   437 PGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYR 501

  Fly   507 KI----SKN 511
            ||    |||
Mouse   502 KIKSLWSKN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	122/473 (26%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	127/470 (27%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	134/505 (27%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840737
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790