DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	551	Identity:	155/551 - (28%)
Similarity:	268/551 - (48%)	Gaps:	114/551 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSP------------------FP---SEEPVKNIY----DIYV 72
            ||:.:....|..|...|||:|.:.|                  ||   |::.::|.:    |::.
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENFFIKFVDVWT 98

  Fly    73 PEVLN----SFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREIL-RPGKAQFDLII 132
            .|:..    |:..||:.|         .|..:::..::.|||.:|    :|:: :..:::||:::
Mouse    99 YEMPRDTCLSYSPLLQNM---------IDEFSDYFLSLCKDVVSN----KELMTKLQESKFDVLL 150

  Fly   133 VDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQS------------------ 179
            .|                |:   |.||      |::.....:.:|.|
Mouse   151 SD----------------PV---ASCG------ELIAELLQIPFLYSIRFSPGYQIEKSSGRFLL 190

  Fly   180 PSSYL-YNLDTFGGRVAHVVE----VAISWFN-WHWRY-EQKHEALYKKYFPK---IAETKPLSE 234
            |.||: ..|...||::..:..    :.:.:|: |...: ::|.::.|.:|..:   :.||...:|
Mouse   191 PPSYVPVILSGLGGQMTFIERIKNMICMLYFDFWFQMFNDKKWDSFYSEYLGRPTTLVETMGQAE 255

  Fly   235 ISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTN 299
                  :.|:..::.|..|.|.:|||..|||:|. :..|.|.:|:|:|:|.||:|||:.||||:.
Mouse   256 ------MWLIRSNWDLEFPHPTLPNVDYVGGLHC-KPAKPLPKDMEEFVQSSGDHGVVVFSLGSM 313

  Fly   300 VRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHG 364
            |  .||.:::...:..|...:||:|||||:.:....:..|..|.|||||.|||.|||.|.|:|||
Mouse   314 V--SNMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHG 376

  Fly   365 GMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEV 429
            |.....|:|::|.||:|:|.|.:|..|:.|:...|..::||...|:..::...:.:::....::.
Mouse   377 GANGVYEAIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEEVIENPFYKK 441

  Fly   430 TARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVI 494
            .|......:.|||||||:.||:|..:|:|||.|.|:|..|..|:::.:|||||:|.:|..:...|
Mouse   442 NAMWLSTIHHDQPMKPLDRAVFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLDVIGFLLSCVATTI 506

  Fly   495 IAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            :..:..::|..         |..|||:.|.|
Mouse   507 VLSVKCLLFIY---------RFFVKKENKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	134/485 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/508 (29%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	140/501 (28%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	153/548 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840410
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690