DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-31

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	128/545 - (23%)
Similarity:	226/545 - (41%)	Gaps:	73/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLFPGFLYGA---RILALFPVPSHSHYYHALPYLKNLASLGHEIT---SVSPFPSEEPV-----K 65
            :.||..|..:   .||...||...||..........|...||.:|   ||:.......:     |
Worm     5 IFFPILLVASEPLNILVYSPVFGGSHSKFMGNIADTLTEAGHNVTFLVSVADVTRRHEIGVKLTK 69

  Fly    66 NIYDIYVP-----EVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRP-G 124
            |:..:..|     :|....||:|:.:.|.:|....|....||...:.:.........|||.:. .
Worm    70 NVIIVDKPNFSQDDVEIDMDEVLRPLWTIQNRPSDFATCFEFFIQMMQTTCAEFTSNREIFKKLS 134

  Fly   125 KAQFDLIIVD------IWKYDA-------FYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSY 176
            |.:|.:.|.:      :..:||       ..|...::|..:             ...|.|..|||
Worm   135 KTEFHVAIAEPVSICGLGYFDALGIKKTILASSTTHYEGVV-------------RNSGEPVDMSY 186

  Fly   177 LQSPSSYL-YNLDTFGGRVAHVVEVAISWFNWH------WRYEQKHEALYKKYFPKIAETKPLSE 234
            :....:|. ..:|.|        :...:|.:.|      .|...:..:.|:|..  :..|....:
Worm   187 VPVHGAYFDEKMDIF--------QRYTNWASEHVLAGNLERMFDQEMSEYRKNL--VQSTGHWRD 241

  Fly   235 ISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHID-EQPKA--LAQDLEDFIQGSGEHGVIYFSL 296
            :....:|:..|.:..|..|||.:...:.:||:.:| ||.|:  |.:.:...:: ..|:.:: .|.
Worm   242 LIPSASLMFTNSNPYLDFPRPVLQKTVGIGGITVDMEQIKSEKLPEKINKLLE-KREYNML-ISF 304

  Fly   297 GTNVRTKNMVDDRKRILIEAFGSLPQ-RVLWKFEDEELQ--DIPSNVLVRKWLPQQDLLAHPKVK 358
            |:.|::..|.:..:..::.|..:.|. ..:||:|.::|:  :...||...||:||..||.:|:|.
Worm   305 GSMVKSSTMPEKWRNSILSAIRNFPNVTFIWKYESDDLRWAENVENVHFLKWIPQTALLNNPRVS 369

  Fly   359 LFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATIL-QLL 422
            .|:||||:.||.|....|||.:.:|.|.||..|...:.:||..|.|...|:.:.|:....: :::
Worm   370 AFLTHGGLGSTNELAFIGKPSIIVPIFGDQGRNAPMLARHGGALVLQKFDLENAEVLIDFIGKIV 434

  Fly   423 TEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVL 487
            .:|.:...|:.........|..|.|..|..|.:|........|....|||::|.....|    :.
Worm   435 FDKSYAKNAKTLANLLNASPFSPKELVVKNTEFVGNFGPLTQMDPYIRKLNWFQRTFAD----IY 495

  Fly   488 LVILLVIIAILLIIVFSVCKISKNI 512
            |::.||..:|::|.::.:.|:.:.|
Worm   496 LILFLVYASIIVIPIYVIRKVFRLI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	115/492 (23%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	114/491 (23%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	120/518 (23%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	64/225 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810