DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt-47

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_505595.2	Gene:	ugt-47 / 187570	WormBaseID:	WBGene00011006	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	138/562 - (24%)
Similarity:	231/562 - (41%)	Gaps:	130/562 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGA--RILALFPVPSHSHYYHALPYLKNLASLGHEIT--------SVSPFPS 60
            :..|.||.|  |.||.  :||...|..|.||..........||..||.:|        .|....|
Worm     7 ILLLAILYF--FEYGLAYKILVFSPATSKSHLISNGRIADELAKAGHNVTLLEIDFLGIVDSTKS 69

  Fly    61 EEPVKNIYDIYVPE-------VLNSFD----------ELLKQMTTPKNTW-----EFFDATNEFV 103
            .:.||... :.||:       |:.||.          ||||.....:..:     ||.:  ||.:
Worm    70 AKLVKKTI-VRVPKKMQGFKNVIQSFSEGVMEDEGLFELLKGNIAYQTVYNDLCEEFLE--NEVM 131

  Fly   104 YNITKDVFNND------------------GVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEA 150
            :|..||. |.|                  |::|:.|......|..:      ||.....|.|...
Worm   132 FNKLKDE-NFDAFFAEQLNICGFGYAKALGIQRKFLISSCPFFSHV------YDYTSHPAPYASV 189

  Fly   151 PIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYL--YNLDTFGGRVAHVVEVAISWFNWHWRYEQ 213
            |.           |.:|  :|.| :||:..::.|  ..::||                :::.:.:
Worm   190 PF-----------ISDM--SPEP-TYLERTNNLLRGITINTF----------------FYFSHNR 224

  Fly   214 KHEALYKKY---FPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKAL 275
            ......||:   ||.|      :||.:::.::.:.....:....|.:||::.|||:.:|:....:
Worm   225 LTSIFRKKFGDDFPAI------TEIVRNVDIIFLATDEIIDFSSPTLPNLVHVGGLGVDDDTTEM 283

  Fly   276 AQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFED---------- 330
            ....|..:: .|:.|||||||||...|..:  |:|  ::|:|    ..::.||.|
Worm   284 GPVFEAEMK-KGDKGVIYFSLGTIANTSTI--DKK--VMESF----LEIVKKFPDYHFLIRADKN 339

  Fly   331 -----EELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFT 390
                 ::..:| |||.|..||||..:|.||:::.||||.|....:|:...|.|::.:||.:||..
Worm   340 DKNTKDKATEI-SNVFVSDWLPQPAILHHPRLRTFITHAGYNGLMEAALAGVPLITIPFMFDQNL 403

  Fly   391 NVDHIKKHGFCLSLNYHDMTSD--ELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWT 453
            |...|:|.|:.:..:.....::  .::..|.::||...:...|.......|::||...:..:..|
Worm   404 NSRAIEKKGWGIRRDKKQFLTEPNAIEEAIREMLTNPSYTKQAHRVRDLMRNKPMGARDRFIKTT 468

  Fly   454 HYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVII 495
            .:|:::.|...:...||.||...:::||::.....|....||
Worm   469 EWVIQNGGVHELLTEGRDLSIIKYYNLDIIVPCFFVAFYFII 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	128/526 (24%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	124/520 (24%)
ugt-47	NP_505595.2	UDPGT	23..527	CDD:278624	131/544 (24%)
ugt-47	NP_505595.2	egt	<230..509	CDD:223071	78/294 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14096
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810