DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-34

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_505728.2	Gene:	ugt-34 / 185120	WormBaseID:	WBGene00009255	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	127/547 - (23%)
Similarity:	229/547 - (41%)	Gaps:	56/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FYLIIL-LFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSP-----FPSEEPVK 65
            |.|.:| |.|........|...|:.:|||:.........|...||.:|.:.|     :.:.:.::
Worm     8 FSLFLLHLLPQLTLSYNYLVFCPLFAHSHHKFLAKIADTLTEAGHNVTFLMPIIHREYENVKYLE 72

  Fly    66 NIYDIYVPEVLNSFDELLKQ---MTTPKNTW---EFFDATNEFVYNITK--DVFNNDGVRREILR 122
            :..||...:.....:|:.:.   .|..||.:   .|..|...|....||  |:...|....:.|:
Worm    73 HTTDIVYIQPDKELEEIAQNADYSTFWKNDFGILTFIPAIERFFRMFTKVHDILKKDLSVLDNLK 137

  Fly   123 PGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEM------VGNPSPMSYLQSPS 181
            ..|  ||.:|.:...:.| :.:..|.|  |..:.|   .|.:..|      :|.||      ||:
Worm   138 NRK--FDAMIFESLAFCA-HPIREYLE--IKTIFP---SWSMTHMTELSQAIGEPS------SPT 188

  Fly   182 SYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQ 246
            .....:..||.::.....:..:..::.:.:..:...|....:|.  :|....||......:..|.
Worm   189 FLPITISPFGDKMTFKERLLNTLADFTFTHIFQPPTLTSFKYPH--QTFDFKEILSQAPFIFFNS 251

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDF--IQGSGEHGVIYFSLGTNVRTKNMVDDR 309
            :..|..|||.:...||:||:.::.....|.:..|::  |....:..|: .|.|:.:|:..|..:.
Worm   252 NPFLDFPRPTLTKTIEIGGISVNATLMRLEKLPEEYNTILNLKQQNVL-ISFGSMLRSSEMPVEY 315

  Fly   310 KRILIEAFGSLPQ-RVLWKFED---EELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTI 370
            |..:.:...|.|. ..:||:|:   |..:::| |....||:||..|||..::..||||.|:.|..
Worm   316 KDTIAQVVRSFPSVTFIWKYENNNVEFAENLP-NFHFFKWVPQTALLADSRLSAFITHAGLGSIN 379

  Fly   371 ESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTS-DELKATILQLLTEKRFEVTARIA 434
            |..:.|||.:.:|.|.||..|...:.:|...:.|:..|:.. |.|:..:..:|.:|.:...|.:.
Worm   380 ELSYIGKPAILVPIFADQLRNAKMLVRHNGSIELDKKDLGKFDVLRDAVDAILNDKSYTNNAILL 444

  Fly   435 GARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILL 499
            ..:...||..|.:..|.:..:..:....|.:....||:|||:...:|::  :.|.....|...:.
Worm   445 SQQLESQPFSPHDLLVKYAEFGAKFGELPSLDPHYRKMSFFSFFMIDII--LFLTATFAIFVSIS 507

  Fly   500 IIVFSVCKISKNISTRLVVKKQRKQKV 526
            :.:|.|  ..|::..       ||:|:
Worm   508 LYLFRV--FFKSVFV-------RKEKI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	112/480 (23%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	111/476 (23%)
ugt-34	NP_505728.2	UDPGT	35..518	CDD:278624	116/504 (23%)
ugt-34	NP_505728.2	Glycosyltransferase_GTB_type	<248..500	CDD:299143	68/255 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860