DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-36

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_504820.2	Gene:	ugt-36 / 184266	WormBaseID:	WBGene00017315	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	125/532 - (23%)
Similarity:	228/532 - (42%)	Gaps:	61/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LALFPVPSHSHYYHALPYLKNLASLGHEITSVSP-----FPSEEPVKNIYDIYVPEVLNSFDELL 83
            |...|:..|||..........|...||.:|..:|     |...:.||:|..:.   .|:..|.|:
Worm    26 LVFCPLFGHSHTTFFAKIADTLTYAGHNVTFFTPTIVRKFSKIQYVKSITHVL---QLDPSDRLV 87

  Fly    84 K--QMTTPKNTWEFF---DATNEFVYNITKDVFNNDGVRR--------EILRPGK-AQFDLIIVD 134
            |  .|...|:..:|:   .:.:|.:..|  |.|||..|.:        .:|...| ..||::|.:
Worm    88 KLGSMFEEKDVSKFWYRDSSLSEMLPMI--DTFNNMFVEQAAVISRNLHVLDDLKEMNFDVMIFE 150

  Fly   135 IWKYDAFYSLAAYFE----APIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVA 195
            .:...| |.:..|.|    .|...||   .|:.:.:.:|.|..:|.:..|:|...:..:...|:.
Worm   151 HFVEPA-YLVLDYLEIQKFIPATSLA---FDYNMVKSIGEPLMLSTVPLPTSEYSDRMSLPQRLI 211

  Fly   196 HVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNV 260
            :.:...|  |:   ....|::  |:.|.|..|.....| |....:.|..|.:..:..||..:...
Worm   212 NAINPLI--FD---NLIPKNK--YRSYRPPYAPINTKS-IEPFCSAVFTNSNPYIDYPRATLEKN 268

  Fly   261 IEVGGMHIDEQPKALAQDLEDFIQGSGEHG--------VIYFSLGTNVRTKNMVDDRKRILIEAF 317
            ::|||:.:|.. |..:|.:      |.|..        .:..|.|:.:.:|:|..:.|..:....
Worm   269 VQVGGISVDID-KLKSQKV------SNEWDAVLNLRPKTVLVSFGSIMLSKDMPINNKITIATVL 326

  Fly   318 GSLPQ-RVLWKFE--DEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPM 379
            |..|. ..:||:|  |....:...|:....|:||..|||.|::..|.||.|:.|..|..:.|||.
Worm   327 GKFPDVTFIWKYETNDTSFANGTENIHFSNWVPQTALLADPRLSAFFTHAGLGSVNEVSYLGKPT 391

  Fly   380 LGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTS-DELKATILQLLTEKRFEVTARIAGARYRDQPM 443
            :..|.|.||..|...:.:|...:.::.:|::: |:::..:.::|.::.::..|.....:..:||:
Worm   392 IMCPIFADQMRNAKMLARHNGSIEISKYDLSNGDKIEEALSKILFDESYKTAAEKLAHQLANQPV 456

  Fly   444 KPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKI 508
            ||.|..|....:..:....|.:....|::||..:..:|:...:|..::|.:..:..:......|:
Worm   457 KPKELLVRHAEFAAQFGHLPSLDPHSRQMSFIQYFLIDLTAIILSTVILFLFVLFKLGKLMYSKL 521

  Fly   509 SKNISTRLVVKK 520
            ..|:|  ||.:|
Worm   522 PFNLS--LVKQK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	112/471 (24%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	114/485 (24%)
ugt-36	NP_504820.2	Glycosyltransferase_GTB_type	6..507	CDD:299143	119/504 (24%)
ugt-36	NP_504820.2	YjiC	25..455	CDD:224732	106/452 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860