DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-23

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001076755.1	Gene:	ugt-23 / 181205	WormBaseID:	WBGene00007650	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	132/520 - (25%)
Similarity:	227/520 - (43%)	Gaps:	61/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNIYDIY--VPEVLNSFDELLK 84
            :||....:..|||.......:..|...||::|.|.|. .:...||...|.  ..:::...||
Worm    20 KILVYSNLFGHSHIKFVGSVVDTLVDAGHDVTVVLPV-IDSTQKNRTSIKSGAKQIIIDADE--- 80

  Fly    85 QMTTPKNTWEFFDATNEFVYN-----------------ITKDVFNNDGVR----REILRPGKAQ- 127
                  ...|.|..|.:|:.|                 |...:|.....:    .|:|...|::
Worm    81 ------EVVEIFSQTEKFLSNMWTMEMSNPLMMWMNPRILTQLFGKQCTKVMKLSELLDQLKSEK 139

  Fly   128 FDLIIVDIWKYDAF-YSLAAYFEAPI-IGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTF 190
            |||.|.:  .:|:. |.:..|.:.|. :.:..|.....:.:::|.|...||:....|...:..|.
Worm   140 FDLAITE--AFDSCGYGIFEYLQIPAHVSILSCARMDHVSDVLGQPIAPSYVPGTQSLYSDRMTM 202

  Fly   191 GGRVAHVVEV--AISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPP 253
            ..|..:.::.  ..|.|:....||   .|..||.   :...:...||..:.:.:|.|....|..|
Worm   203 TQRFLNYLQFLNGNSMFSDIGDYE---SANAKKL---LGVERSWREILPESSFLLTNHIPVLEFP 261

  Fly   254 RPYVPNVIEVGGMHIDEQPKALAQDLE---DFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIE 315
            .|....::.:||:.:::..:.|  .||   |.:....:..|| .|.|:|:::.:|.|:.|:.|.|
Worm   262 APTFDKIVPIGGISVNKNKETL--KLEHYFDTMVSMRKKNVI-ISFGSNIKSMDMPDEYKKSLAE 323

  Fly   316 AFGSLPQ-RVLWKFE---DEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            .|..:|. ..:||:|   |::......|:...:|:||.:|||..:|..||||||:.|..|....|
Worm   324 LFQLMPDVTFIWKYENLADKKYTCGIMNINRVEWIPQTELLADSRVDAFITHGGLGSVTELATMG 388

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDE-LKATILQLLTEKRFEVTARIAGARYRD 440
            ||.:.:|.|.||..|.:.:|:||....|:..|:.:.| |:.|:.:::.:..:...|:.......:
Worm   389 KPAVVIPIFADQTRNAEMLKRHGGAEVLHKTDLANPETLRKTLRKVMDDPSYRQNAQRLAEMLNN 453

  Fly   441 QPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVL--GTVL--LVILLVIIAILLII 501
            ||..|.||.|....:..|....|.|...||..:...:::||:|  .|:|  ||:.|.|.|:.:::
Worm   454 QPTNPKETLVKHVEFAARFGKLPSMDPYGRHQNIIEYYNLDILAIATILLTLVVYLKIFAVGVVV 518

Fly 502 501
Worm 519 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	118/474 (25%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	122/488 (25%)
ugt-23	NP_001076755.1	UDPGT	20..526	CDD:278624	132/520 (25%)
ugt-23	NP_001076755.1	Glycosyltransferase_GTB_type	40..474	CDD:299143	113/454 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810