DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt-57

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	129/552 - (23%)
Similarity:	237/552 - (42%)	Gaps:	116/552 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KNLASLGHEITSVSP--FPSEEP--VKN----IYDIYVPEVLNSFDELLKQM--TTPKNTWE--- 94
            :.||...|.:.|:.|  .| |||  ||.    :.:..:..|||.  :|.|.:  ..|...|.
Worm    39 QQLALRHHNVISIKPVLIP-EEPRLVKPKLHLVREKVIKNVLNK--DLFKPLEDAVPNAAWRSTY 100

  Fly    95 --------FFDATNEFVYNITKDVFNN--DGVRREILRPGKAQFDLIIVDIWKY------DAFYS 143
                    ::.|.|...|.:..   :|  |.:::|.|       ||.||    |      :|...
Worm   101 DFDNYLEPYYKAHNASCYKLLN---SNLVDSLKKESL-------DLAIV----YSGNPCLNALTH 151

  Fly   144 LAA----YFEAPIIGLAPCGIDWKIDE-MVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAIS 203
            |.|    ||:..  ||.        || ::...:|:..| :|.|:.:..::.|..:.::.:.::.
Worm   152 LVAVPTIYFDTE--GLT--------DETLIAAGAPIDLL-TPPSHCFIAESKGYPILNLYKNSVC 205

  Fly   204 WF-----------------NWHWRYEQKHEALYK---------KYFPKIAETKPLSEISQDIALV 242
            :|                 :.|...::....:::         |.||.:      :.:.|..|..
Worm   206 YFQEMIAQLGLPAVSSLVSSRHRLLDEPITNIFRTDYTIKKRFKNFPNV------NTLKQQSAAY 264

  Fly   243 LVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVD 307
            .||....|.|||....|||.|||:||| .||.|.......| .|.:.|:|..|.||...:..|.:
Worm   265 FVNTDPLLEPPRALPLNVIPVGGLHID-HPKPLFSPWNTTI-ASAKEGLIIVSFGTQADSSKMSE 327

  Fly   308 DRKRILIEAFGSL-PQRVLWK------FEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGG 365
            ...:.:::|..:| ..|:.|:      .:..:::.||.::.:..::||.|||||...|||:|:||
Worm   328 YHAKAILKALTNLNDYRIYWRIGPNMHLDGIDIEKIPKHINLTTFIPQNDLLAHKSCKLFVTNGG 392

  Fly   366 MQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVT 430
            |.|.:|::.:|.|::|:|.:.....|:..:...|..:.::..|:....|...:.::|...:::.|
Worm   393 MSSVMEAVAHGVPIVGVPLYGSNRYNLQKVSNKGLGIVIDKDDLNEISLYGAMKKVLESAKYKNT 457

  Fly   431 ARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGR----KLSFFTHHSLDVLGTVLLVIL 491
            |:.....::.:...|...|:....::.||....:|:.|.:    ::.|:         .:||:||
Worm   458 AKEMSKEFKSRTTSPFAAALHVIDHIGRHHSFAYMQPAFQPIYTRVDFY---------LLLLIIL 513

  Fly   492 LVIIAILLIIVFSVCKISKNISTRLVVKKQRK 523
            |.:|.:.|...|.:...:.|:....|::.:||
Worm   514 LPVIPLHLFFTFCIKSSAMNVQDNKVLEAERK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	114/484 (24%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	117/511 (23%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	73/317 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910