DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt-1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	128/560 - (22%)
Similarity:	232/560 - (41%)	Gaps:	75/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSE-----EPVK 65
            ||.|:..|  .|.|....|.:.||..:||..........||:..|.:|.:..:..|     ...|
Worm     4 LFLLLTSL--TFCYSHNFLVVSPVFGYSHMKFMNKVADTLANGDHNVTILQTYNYEHFGKIRMAK 66

  Fly    66 N----IYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNN---DGVRREILRP 123
            |    |.|.::.|.....:|               ::.:.|.|....::.||   ..:....:..
Worm    67 NTNVEILDYHLDESKAVSNE---------------NSASAFKYMWNTEIINNPITGAIATSTVLY 116

  Fly   124 G--KAQFDLIIVD----IW----KYDAFYS---------LAAYFEAPIIGLAPCGIDWKIDEMVG 169
            |  |...:.:::|    .|    .:|.|.|         |..:.:..||.:............:|
Worm   117 GEMKTMCEKVLLDKKLHKWILSKNFDGFISEPFDFCGLYLGDHLKLNIIPMHSSTKSLPSVYAIG 181

  Fly   170 NPSPMSYLQSPSSYLYNLDTFGGRVAHVV-----EVAISWFNWHWRYEQKHEALYKKYFPKIAET 229
            .||.:::|.|..:......|...|:..::     |:|.|.. :..:|:|..:.|.       .:.
Worm   182 EPSLLNFLPSMRTKFGTEQTVFDRIGDIIALPCLELAFSKL-FEKQYKQASQLLN-------GDV 238

  Fly   230 KPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYF 294
            :...||.|.......|.:..:..|.|.:|..:.:||..|| .||.|..:.|.....|.....:..
Worm   239 RHWKEILQTATFYFSNANDFIAFPTPSLPKHVHIGGFTID-PPKNLKLEEEYNKILSLRKSTVLI 302

  Fly   295 SLGTNVRTKNMVDDRKRILIEAFGSLPQRV-LWKFEDEE---LQDIPSNVLVRKWLPQQDLLAHP 355
            |.||.:::.:|.:..|..:|:.|..||... :||:|.|:   ::.:|:|.:::||:||..|||.|
Worm   303 SFGTVIQSADMPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERLPNNAILKKWVPQPALLADP 367

  Fly   356 KVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDM-TSDELKATIL 419
            ::|||:||||:.||:|..:.|||.|.:|.|.||..|...:.:||.....:.:|: .:::|.:.|.
Worm   368 RLKLFVTHGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHGGATVFDKYDLEDAEKLTSAIK 432

  Fly   420 QLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLG 484
            :::..:.|...:.......|:||:.|....:....:..:......:.......:|..::.||...
Worm   433 EIIGNEEFNKKSHHIADLLRNQPIDPKANLLKHVEFSAKFGRVDALEPYNVHYNFVQYYMLDAFA 497

  Fly   485 TVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQ 524
                    :|.:||:||.:....:.|.:...:...|.:|:
Worm   498 --------IIFSILIIIFYLAHLLFKFVYKHVFKTKSKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	117/495 (24%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	111/491 (23%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	118/531 (22%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	78/312 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810