DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	142/576 - (24%)
Similarity:	226/576 - (39%)	Gaps:	115/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSE-EPVKNIYD 69
            ||.|:.||   .:...:||...|..|.||..........|...||::..   |.:| ||:.....
Worm     5 LFLLLSLL---AVDAGKILVYSPSISRSHLISNGRIADALVDAGHDVVM---FITEYEPLTEFTG 63

  Fly    70 IYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVF--------------NNDGVRREI 120
            ....:|:.     :|..:|  ...|..|...|::.:.::..|              ::...|||.
Worm    64 TKKAKVIT-----MKGFST--KFAEDMDGIGEYLLSSSRLSFLERLMFEKTCTGACDDLMTRREE 121

  Fly   121 LRPGKA---------QFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSY 176
            |...:|         |.||..|.|.:|....:.......||:.        .:...:|.|:|.||
Worm   122 LEQLRAYNFDVAFSEQIDLCGVGIVRYLGIKNHLWISTTPIMD--------AVSYNLGIPAPSSY 178

  Fly   177 LQSPS-----------SYLYNL-DTFGGRVAHVVEVAISWFNWHWRY-EQKHEALYKKYFPKIAE 228
            :.:..           ...:|| ...|..:.|             || ......:::||.|....
Worm   179 VPTIEENDNGDKMDFWQRTFNLYMKIGSILIH-------------RYGTDGTTEVFRKYIPDFPN 230

  Fly   229 TKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIY 293
            .:   ||:.:.:|..||....|..|||.:...|.|||:.|.:..|.|.:...: |...|:.||:.
Worm   231 VR---EIAANSSLCFVNSDEVLDLPRPTITKAIYVGGLGIPKVSKPLDKKFTN-IMSKGKEGVVI 291

  Fly   294 FSLGTNVRTKNMVDDRKRILIEAFGSLPQ-------RVLWKFED--------------EELQDIP 337
            .|||:               |..||.||.       |.:.:..|              ::|.:..
Worm   292 ISLGS---------------IIPFGDLPAAAKEGVLRAIQEISDYHFLIKIAKGDNNTKKLVEGI 341

  Fly   338 SNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCL 402
            .||.|.:||||.|:|:||::|||:.|||:...:|:.....|.:.:|.|.|||.|...::|.|...
Worm   342 KNVDVAEWLPQVDILSHPRLKLFVMHGGINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGK 406

  Fly   403 SLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRV 467
            .|...|:..:..|.|:|.:|....::..|...|...||:|..|.|....||.:.:.|.....:.|
Worm   407 VLLKLDIGYESFKNTVLTVLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHV 471

  Fly   468 AGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRK 523
            .|.:|:...:::|||:..||.|.:.|:...:....|..||.....:    :||.:|
Worm   472 EGSRLNTIIYYNLDVIAFVLFVFVAVLHVFIYAFKFLCCKKRSQSN----IKKSKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	126/512 (25%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	123/508 (24%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	136/559 (24%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	88/341 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710