DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	147/576 - (25%)
Similarity:	249/576 - (43%)	Gaps:	139/576 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YGARILALFPVPSHSHYYHALPYLKNLASL----GHEITSVSPFPSEEPVKNIYDI--------- 70
            |.|:||...|:...||    :.::..||.:    |.|:|...||  ...:||:..|
Worm    17 YAAKILIFNPIFGFSH----VKFVSKLADIIADHGQEVTLFQPF--HLALKNLDGIVKNKNIEII 75

  Fly    71 -YVPEVLNSFDELLK--QMTTPKNTWEFFDAT-----------------NEF---VYNITKDVFN 112
             |.|:   .:|:|||  ..|.|    :|:|:.                 .||   ...:.||
Worm    76 NYYPD---HYDDLLKLETQTFP----DFWDSQLMNNPVLMAFMLPRILGGEFKKTTIQLIKD--- 130

  Fly   113 NDGVRREILRPGK-AQFDLIIVDIWKYDAFYSLAAYFEAPIIG-LAPCGIDWKIDEMVGNPSPMS 175
                 :|||:..| .:||:.|.:.::....| ::.:...|.|. |:...:| ..:|..|..|...
Worm   131 -----KEILKKLKDKKFDVAISETFELTGMY-MSHFLGVPCIPILSAVRLD-IFNEAFGQSSAFG 188

  Fly   176 YLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDI- 239
            ||....|.|.....|..|:..|                     |:.:|.|:| .:.:::...|:
Worm   189 YLTQQGSKLAPDAGFLDRLNDV---------------------YRDFFSKMA-FRGMAQYQNDVI 231

  Fly   240 ------------------ALVLVNQHFTLGPPRPYVPNVIEVGGM--------HIDEQPKALAQD 278
                              .:.:.|.:..|....|....::.:||:        |:|    ||.::
Worm   232 EKAAGHVVPYWKDLVKEAPVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVD----ALPEE 292

  Fly   279 LEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRV-LWKFEDEELQ---DIPSN 339
            .|..::  .:...:..|.|:.:|:..|.::.|..||:.|.|||..: :||:|.::|:   .:|.|
Worm   293 YEIILK--EKETTVLISFGSVIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKN 355

  Fly   340 VLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSL 404
            |.::||:||..|||..:||||:||||:.||:|..:.|||.|.:|.|.||..|.|.:.:||..::.
Worm   356 VHLKKWVPQPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAY 420

  Fly   405 NYHDMT-SDELKATILQLLTEKRFEVTARIAGARYRDQP-------MKPLETAVWWTHYVLRHKG 461
            :..|:. ..:|..|:..|:|..::|..|:.......:||       ||.||.|:.:.:  ||.:
Worm   421 DKFDLVDGKKLTETVRDLVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPN--LRSQ- 482

  Fly   462 APHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLV 517
            .|.:...|.    ..|:.|||:  |.|:.:.:|.|.:...:  ||:|...|.::.|
Worm   483 IPEINQVGP----IAHYYLDVI--VFLIFVSIITAYISFQI--VCRILSRILSKKV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	132/518 (25%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	133/527 (25%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	85/308 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810