DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt-53

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	150/567 - (26%)
Similarity:	240/567 - (42%)	Gaps:	113/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGARILALFPV--PSHSHYYHALPYLKN----LASLGH----------EITS 54
            |.:|.:|:  .|.....||..:.|  |||      :.||:|    |.:.||          |:.:
Worm     4 LIFLTVLI--NFSSCLNILFYYAVIGPSH------IAYLRNTIGKLLARGHNVDVVFAVYNELAN 60

  Fly    55 VSPFPSEEPVKNIY------DIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNN 113
            :..||.   |:.||      ..|..:..|.|..:.::..||...:|.|   :|..|.:.| :..|
Worm    61 LDLFPD---VRRIYYNRHADPDYWKKNANHFSNMFEKSPTPLGEFEIF---HESGYQLCK-IAIN 118

  Fly   114 DGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQ 178
            |....|.|:.|            |||..:| :.|        .|||.  .:....|.||..|.:.
Worm   119 DLKLIEFLKSG------------KYDIGFS-SDY--------DPCGN--ILMTAAGIPSIGSLIA 160

  Fly   179 SPSSYLYNLDTFG-GRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAET------------- 229
            :| .:|.::.:.| ..||.|...::        |.:...:||.|.|..|..|
Worm   161 TP-IFLPHIVSAGLPTVASVYGTSL--------YPEHDSSLYDKIFNLIRLTYYHYAISPDMDRK 216

  Fly   230 -------------KPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLED 281
                         ..:..|.:.|.::.||.|..|...||..|.:..:|||.| .:.|.|..:.|.
Worm   217 YNNLITKRFGNNFPDVGTIERGIDIIFVNSHDFLEQQRPMSPKIKYIGGMAI-RKAKQLPDEFEK 280

  Fly   282 FIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQ-RVLWKFEDEELQ-DI---PSNVL 341
             |....:...:.||.||.|.|..|....:|..:.||...|. ..|||::..||. ||   ..|:.
Worm   281 -ILSVPKSAYVLFSFGTQVPTAKMPLPIRRNFVGAFKKFPNVTFLWKYDSLELDADIFQGVENIH 344

  Fly   342 VRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNY 406
            ..:||||.:||...:|||||:|.|:.|.:|:...|.|:|.:|.|.||..|..:.:..|..|.|:.
Worm   345 RLEWLPQTELLHDNRVKLFISHMGLNSYLETATAGVPVLSIPLFADQQNNAQNTRDRGMGLLLDR 409

  Fly   407 HDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPH-MRVAGR 470
            ..:|:..:::.:.:||...::...||.......::|.|..:|.:.|..:..|:.|... :::.|.
Worm   410 DKLTTKNIESALHELLENPKYLSNARSISKMILEKPDKANDTFIHWLEFTARNPGLGRVLKLPGA 474

  Fly   471 KLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLV 517
            :||.|.::..|        |||::..||.||:.:|.: :.|:.:|.:
Worm   475 ELSPFYYYCGD--------ILLLVFCILFIILHTVLR-TINLPSRKI 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	134/508 (26%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	130/503 (26%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	137/522 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14449
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710