DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt-44

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_501933.1	Gene:	ugt-44 / 177939	WormBaseID:	WBGene00008486	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	146/556 - (26%)
Similarity:	251/556 - (45%)	Gaps:	72/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIILLFPGFLYG----ARILALFPVPSHSHYYHALPYLKNLASL----GHEITSVSPF------- 58
            |||:.:...:.|    .::|...|:..|||    |.::..:|::    |:.:|.:.|.
Worm    10 LIIVYYSQTINGIERPKKVLVFMPISGHSH----LKFMGTIANILQDEGYNVTLLLPILDEGLRD 70

  Fly    59 --PSEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEF------VYNI----TKDVF 111
              |....:||...:...|.|...:...:.....:|||........|      |.||    .|:||
Worm    71 TTPLVRKIKNRILVEQSEELIEANAQFRAGGGRENTWVMNSGIIGFLKLGTKVANICKASCKNVF 135

  Fly   112 NNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAY--FEAPIIGLAPCGIDWKIDEMV-GNPSP 173
            .|:.: ...||  ..:||:.|.:. .|...::|..:  .|..|...:..|::  :.::. |....
Worm   136 QNEDL-INYLR--DQRFDVAISEP-LYTCGFALFDHLGIETTISTDSHLGLE--VSKIAHGASIS 194

  Fly   174 MSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWR---YEQK---HEALYKKYFPKIAETKPL 232
            .|||.:..|......|..||..:.||   |:||:::.   ||.:   .|.:||       ..|..
Worm   195 TSYLPAVFSSGSERMTLIGRAKNYVE---SYFNYYFNSKIYENELAGIEGIYK-------NGKGW 249

  Fly   233 SEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLG 297
            .|:|:..|.:.||.:..:..|.|.....||:||:......:....:..|.:....:..|: .|.|
Worm   250 RELSRKNAYMFVNSNPQMDIPSPRTSKFIEIGGISSGPVKQERLPEEYDRVLSLRKKNVL-ISFG 313

  Fly   298 TNVRTKNMVDDRKRILIEAFGSLPQRV-LWKFEDEELQDIP------SNVLVRKWLPQQDLLAHP 355
            ||.::..|.||.|..||:.|.|:|... :||:|:..:..:.      :||::..|:||..|||.|
Worm   314 TNAKSMFMSDDMKESLIKTFESMPDTTFIWKYENTTVDIVKQYNKRINNVMLTDWMPQTALLADP 378

  Fly   356 KVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTS-DELKATIL 419
            ::.||:||||:.||.|....|||.:.:|.|.||..|...:::|...|.|..:|:|: .:::.||.
Worm   379 RLTLFVTHGGLGSTNEVAFSGKPSIMVPVFGDQTRNARMLERHEVALVLTKYDLTNFKKVRGTIR 443

  Fly   420 QLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPH-MRVAGRKLSFFTHHSLDVL 483
            ::|.:|.:.:.|.......|:||..|.|..:.:.::|.|. |.|| :.....::||...:.:|
Worm   444 KMLNDKSYSMKAEKLAQMLRNQPESPKEIFIKYFNFVARF-GKPHGLDSYAAEMSFIEFYYID-- 505

  Fly   484 GTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVK 519
               .:.||.:....|.:||..|.:.|.|::..:.:|
Worm   506 ---FMAILSIFSVALYMIVSKVLRASHNLTNLVSIK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	131/495 (26%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	130/491 (26%)
ugt-44	NP_501933.1	UDPGT	27..510	CDD:278624	133/509 (26%)
ugt-44	NP_501933.1	egt	<250..519	CDD:223071	81/275 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810