Protein Alignment Ugt35E1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 154/574 - (26%)
• Similarity: 249/574 - (43%)
• Gaps: 113/574 - (19%)

  Fly     1 MLASGLFYLIILLFPGFLY--GARILALFPVPSHSHY---------------------------- 35
            |....:..|:..|.||.|.  .|:||.:..| ..|||
Human     1 MAGQRVLLLVGFLLPGVLLSEAAKILTISTV-GGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFM 64

  Fly    36 ------------YHALPYLKNLASLG----------HEITS-VSPFPSEEPVKNIYDIYVPEVL- 76
                        |..:.||:.....|          :::.| ::|...:...|..:|.::.|.|
Human    65 PGLSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLG 129

  Fly    77 --NSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLIIVDIWKYD 139
              ..|:.||       |..|:.........| .||:.  |.::.|       .||::||:.:.|.
Human   130 GRGKFENLL-------NVLEYLALQCSHFLN-RKDIM--DSLKNE-------NFDMVIVETFDYC 177

  Fly   140 AFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISW 204
            .|. :|.....|.:.:......   ....|.|.|:||:....|.|.:...|.|||.:.    :.:
Human   178 PFL-IAEKLGKPFVAILSTSFG---SLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNF----LMF 234

  Fly   205 FNWHWRYEQKH-----EALYKKYFPKIAETKP-LSEISQDIALVLVNQHFTLGPPRPYVPNVIEV 263
            |::..|  |:|     :...|::|.:  .::| ||.:.....|..:|..|.....||.:||.:.|
Human   235 FSFCRR--QQHMQSTFDNTIKEHFTE--GSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYV 295

  Fly   264 GGMHIDEQP-KALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWK 327
            ||:.  |:| |.:.||||:||...|:.|.:..:||:.|.|....:..|. :..||..|||.|:||
Human   296 GGLM--EKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKE-MNNAFAHLPQGVIWK 357

  Fly   328 FE------DEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFY 386
            .:      |..|   .:||.:..||||.||||||.::||:||||..|.:|:|.:|.||:|:|.|.
Human   358 CQCSHWPKDVHL---AANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFG 419

  Fly   387 DQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVW 451
            ||..|:..::...|.:|:....:.::.|...:.|::.:||::..|..|....|..|:.|.:..|.
Human   420 DQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVG 484

  Fly   452 WTHYVLRHKGAPHMRVAGRKLSFFTHHSLDV--------LGTVLLVILLVIIAI 497
            |..:||:..||.|::....:..:...:.|||        |||:.|...|:.:|:
Human   485 WIDHVLQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAV 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	Glycosyltransferase_GTB-type	33..484	CDD:471961	138/525 (26%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	142/530 (27%)