DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	532	Identity:	149/532 - (28%)
Similarity:	267/532 - (50%)	Gaps:	76/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSP------------------FPSEEPVKNIYDIYVPEVLN-- 77
            ||:.:....|..|...|||:|.:.|                  ||:.....::.:.:: ::||
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVTKDDLENFFI-QLLNVW 97

  Fly    78 ----------SFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLII 132
                      |:..|::.|         ||..:.:..::.|||.:|   |:.:.:..:::||:::
Mouse    98 TYELSRDTCLSYSPLMQNM---------FDELSGYYLSLCKDVVSN---RQLMTKLQESKFDVLL 150

  Fly   133 VDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHV 197
            .|...:.. ..:|.....|.:........::|::..|.     :|..||.....|...||::..:
Mouse   151 SDPVAFGG-ELIAELLHIPFLYSLRFTAGYRIEKSSGR-----FLLPPSYVPVILSGLGGQMTFI 209

  Fly   198 VEV----AISWFNWHWRY--EQKHEALYKKYFPK---IAETKPLSEISQDIALVLVNQHFTLGPP 253
            ..|    .:.:|::.::.  ::|.::.|.:|..:   :|||...:|      :.|:..::.|..|
Mouse   210 ERVKNMICMLYFDFWFQMPNDKKWDSFYTEYLGRPTTLAETMGQAE------MWLIRSNWDLEFP 268

  Fly   254 RPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFG 318
            .|.:|||..|||:|. :..|.|.:|:|:::|.||:|||:.||||:.|  .|:.:::...:..|..
Mouse   269 HPTLPNVDYVGGLHC-KPAKPLPKDMEEYVQSSGDHGVVVFSLGSMV--SNITEEKVNAIAWALA 330

  Fly   319 SLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLP 383
            .:||:|||||:.:....:..|..|.|||||.|||.|||.|.||||||..|..|:|::|.||:|:|
Mouse   331 QIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFITHGGANSVYEAIYHGIPMIGIP 395

  Fly   384 FFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLET 448
            .|.:|..|:.|:...|..::||...|:..::...:.:::....::..|......:.|||||||:.
Mouse   396 LFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLDR 460

  Fly   449 AVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNIS 513
            ||:|..:|:|||.|.|:|..|..|:::.:|||||:|.:|..:...::..:..::|..
Mouse   461 AVFWVEFVMRHKNAKHLRPLGHNLTWYQYHSLDVIGFLLACVAATVVLTVKCLLFIY-------- 517

  Fly   514 TRLVVKKQRKQK 525
             |..|.|::|.|
Mouse   518 -RFFVTKKKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	130/466 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	141/489 (29%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	147/529 (28%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	26/145 (18%)
		egt	<270..489	CDD:223071	88/221 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840412
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690