Protein Alignment Ugt35E1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 161/538 - (29%)
• Similarity: 265/538 - (49%)
• Gaps: 87/538 - (16%)

  Fly    33 SHYYHALPYLKNLASLGHEIT----SVSPFPSEEPVK--NIYDIYVPEVLNSFDELLKQM----- 86
            ||:.:....|:.|....|.:|    |.:.|.:..|..  |...|.|....::.|.|::.|
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly    87 ---TTPKNTWEFFDATNEFVYNITKDVFNN------DGVRRE---ILRPGKAQFDLIIVD----- 134
               .||...|.|:....:.:     |.|..      |||.:.   :.|..|..||:::.|
Human   306 DHRPTPLTIWAFYKELGKLL-----DTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTIC 365

  Fly   135 ----------IWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDT 189
                      .:.|...:|.|:..|      ..||   ||      |:|:||:.:..|.|.:..|
Human   366 GDLVALKLGIPFMYTLRFSPASTVE------RHCG---KI------PAPVSYVPAALSELTDQMT 415

  Fly   190 FGGRVAHVVEVAIS-------WFNWHWRYEQKHEALYKKYFPKI-AETKPLSEISQDIALVLVNQ 246
            ||.|:.:.:..::.       |..|:            .|:.|| .....|.|......:.|:..
Human   416 FGERIKNTISYSLQDYIFQSYWGEWN------------SYYSKILGRPTTLCETMGKAEIWLIRT 468

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311
            ::....||||:||...|||:|. :..|.|.:::|:|||.||::||:.||||:.|  ||:.:::..
Human   469 YWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKAN 530

  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            ::..|...:||:|||:::.::...:.:|..:..|:||.|||.|||.|.||||||.....|:|::|
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441
            .||:|:|.|.||..|:.|:|..|..:.:|.:.|||.:|.:.:..::.|..::..|......:.||
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506
            |:|||:.||:|..:|:|||||.|:|||...|::|.:|||||:|.:|:.:...|..::...:||..
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQ 725

  Fly   507 KISKNISTRLVVKKQRKQ 524
            |..|      :.||::::
Human   726 KFGK------IGKKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	138/473 (29%)
		UDPGT	33..484	CDD:278624	152/496 (31%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	157/518 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150197
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0	Normalized mean entropy	S5610
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.640