Protein Alignment Ugt35E1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_652622.3
• Gene: Ugt35E1 / 53504
• FlyBaseID: FBgn0040253
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 161/538 - (29%)
• Similarity: 265/538 - (49%)
• Gaps: 87/538 - (16%)

  Fly    33 SHYYHALPYLKNLASLGHEIT----SVSPFPSEEPVK--NIYDIYVPEVLNSFDELLKQM----- 86
            ||:.:....|:.|....|.:|    |.:.|.:..|..  |...|.|....::.|.|::.|
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWI 305

  Fly    87 ---TTPKNTWEFFDATNEFVYNITKDVFNN------DGVRRE---ILRPGKAQFDLIIVD----- 134
               .||...|.|:....:.:     |.|..      |||.:.   :.|..|..||:::.|
Human   306 DHRPTPLTIWAFYKELGKLL-----DTFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTIC 365

  Fly   135 ----------IWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDT 189
                      .:.|...:|.|:..|      ..||   ||      |:|:||:.:..|.|.:..|
Human   366 GDLVALKLGIPFMYTLRFSPASTVE------RHCG---KI------PAPVSYVPAALSELTDQMT 415

  Fly   190 FGGRVAHVVEVAIS-------WFNWHWRYEQKHEALYKKYFPKI-AETKPLSEISQDIALVLVNQ 246
            ||.|:.:.:..::.       |..|:            .|:.|| .....|.|......:.|:..
Human   416 FGERIKNTISYSLQDYIFQSYWGEWN------------SYYSKILGRPTTLCETMGKAEIWLIRT 468

  Fly   247 HFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKR 311
            ::....||||:||...|||:|. :..|.|.:::|:|||.||::||:.||||:.|  ||:.:::..
Human   469 YWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKAN 530

  Fly   312 ILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYG 376
            ::..|...:||:|||:::.::...:.:|..:..|:||.|||.|||.|.||||||.....|:|::|
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   377 KPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQ 441
            .||:|:|.|.||..|:.|:|..|..:.:|.:.|||.:|.:.:..::.|..::..|......:.||
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   442 PMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVC 506
            |:|||:.||:|..:|:|||||.|:|||...|::|.:|||||:|.:|:.:...|..::...:||..
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQ 725

  Fly   507 KISKNISTRLVVKKQRKQ 524
            |..|      :.||::::
Human   726 KFGK------IGKKKKRE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	Glycosyltransferase_GTB-type	33..484	CDD:471961	152/496 (31%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	157/518 (30%)