DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and Ugt3a1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_997099.2	Gene:	Ugt3a1 / 105887	MGIID:	2146055	Length:	523	Species:	Mus musculus

Alignment Length:	553	Identity:	146/553 - (26%)
Similarity:	253/553 - (45%)	Gaps:	82/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASGLFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEIT-------SVSPFP 59
            |....|.|.:||    |..|:||.:..: |.|||.......:.|...||::.       .:..|.
Mouse     8 LLVSFFLLEVLL----LEAAKILTISTL-SASHYILMNRVSQILQGGGHDVIKLLYEGGDIPDFR 67

  Fly    60 SEEPVKNIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITK------------DVFN 112
            .|.....:.:..:||         .|..|.:|.|.  ...:|:.|..:|            |:.:
Mouse    68 KENSSYQVINWRLPE---------DQQKTFENRWH--RLIDEYAYGRSKYHTLLKIHQYFADLCS 121

  Fly   113 NDGVRREILR-PGKAQFDLIIVDIWKYDAFY---SLAAYFEAPIIGLAPCGIDWKIDEMVGNPSP 173
            :...|::|:. ..|..|||:::|.....:|.   .|...|    :...|....: :|..:.| :|
Mouse   122 HLLSRKDIMELLQKENFDLVLLDSMDLCSFLIVEKLGKRF----VSFLPFQFSY-MDFGLPN-AP 180

  Fly   174 MSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAE-----TKP-L 232
            :||.....|.|.:...|.|||.:::        ..:.:.:|...::.:|...:.|     ::| |
Mouse   181 LSYAPVYGSGLTDQMDFWGRVKNIL--------MFFHFTKKRRDIFSQYGNTVQEHFAEGSQPVL 237

  Fly   233 SEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLG 297
            |::.....|..||..|.|...||..||.:.|||: :|:..:.:.|||||||...|:.|.:..:||
Mouse   238 SDLLLKAELWFVNSDFALDFARPLFPNTVYVGGL-LDKPVQPIPQDLEDFISQFGDSGFVLVALG 301

  Fly   298 TNVRTKNMVDDRKRI--LIEAFGSLPQRVLWKFEDEELQ---DIPSNVLVRKWLPQQDLLAHPKV 357
            :.|   :|:..::.|  :..||..|||.|||..:.....   .:..||.:..||||.||||||.:
Mouse   302 SVV---SMIQSKEIIKEMNSAFAHLPQGVLWTCKSSHWPKDVSLAPNVKIMDWLPQIDLLAHPSI 363

  Fly   358 KLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLL 422
            :||:|||||.|.:|::|:|.||:|:|||.||..|:..::.....:|:....:.::....|:.:::
Mouse   364 RLFVTHGGMNSVMEAVHHGVPMVGIPFFGDQPENMVRVEAKNLGVSIQLQTLKAESFLLTMKEVI 428

  Fly   423 TEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDV----- 482
            .::|::..|..:....:..|:.|.:..|.|..::|:..||.|::....:..:...:.|||
Mouse   429 EDQRYKTAAMASKVIRQSHPLTPAQRLVGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFLL 493

  Fly   483 ---LGTVLLVILLVIIAILLIIVFSVCKISKNI 512
               |||:.|.:.      :|:.|.....||:.:
Mouse   494 GLTLGTLWLSVK------VLVAVTRYLSISRKV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	131/488 (27%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	128/492 (26%)
Ugt3a1	NP_997099.2	UDPGT	24..488	CDD:278624	129/493 (26%)
Ugt3a1	NP_997099.2	egt	<235..488	CDD:223071	83/256 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740