DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	553	Identity:	155/553 - (28%)
Similarity:	263/553 - (47%)	Gaps:	118/553 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSP------------------FP---SEEPVKNIY----DIYV 72
            ||:.:....|..|...|||:|.:.|                  ||   |::.::|.:    |::.
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENFFIKFVDVWT 98

  Fly    73 PEVLN----SFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREIL-RPGKAQFDLII 132
            .|:..    |:..||:.|         .|..:::..::.|||.:|    :|:: :..:::||:::
Mouse    99 YEMPRDTCLSYSPLLQNM---------IDEFSDYFLSLCKDVVSN----KELMTKLQESKFDVLL 150

  Fly   133 VDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQS------------------ 179
            .|                |:   |.||      |::.....:.:|.|
Mouse   151 SD----------------PV---ASCG------ELIAELLQIPFLYSIRFSPGYQIEKSSGRFLL 190

  Fly   180 PSSYL-YNLDTFGGRVAHVVEVAIS--------WFNWHWRYEQKHEALYKKYFPK---IAETKPL 232
            |.||: ..|...||::..:..|...        ||...  .::|.::.|.:|..:   :|||...
Mouse   191 PPSYVPVILSGLGGQMTFIERVKNMICRLYFDFWFQMF--NDKKWDSFYSEYLGRPTTLAETMGK 253

  Fly   233 SEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLG 297
            :|      :.|:..::.|..|.|.:|||..|||:|. :..|.|.:|:|:|:|.||:|||:.||||
Mouse   254 AE------MWLIRSNWDLEFPHPTLPNVDYVGGLHC-KPAKPLPKDMEEFVQSSGDHGVVVFSLG 311

  Fly   298 TNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFIT 362
            :.|  .||.:::...:..|...:||:|||||:.:....:..|..|.|||||.|||.|||.|.|:|
Mouse   312 SMV--SNMTEEKANTIAWALAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVT 374

  Fly   363 HGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRF 427
            |||.....|.|::|.||:|:|.|.:|..|:.|:...|..::||...|:..::...:.:::....:
Mouse   375 HGGANGVYEVIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFY 439

  Fly   428 EVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILL 492
            :..|......:.|||.|||:.||:|..:|:|||.|.|:|..|..|::..:|.|||:|.:|..:.:
Mouse   440 KKNAIWLSTIHHDQPTKPLDRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAV 504

  Fly   493 VIIAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            .|:..:..::|..         |..|||::|.|
Mouse   505 TIVLTVKCLLFIY---------RFFVKKEKKIK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	135/487 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/510 (28%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	147/520 (28%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	153/549 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840411
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690