DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt5f1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_017207383.1	Gene:	ugt5f1 / 100415800	ZFINID:	ZDB-GENE-100406-6	Length:	556	Species:	Danio rerio

Alignment Length:	548	Identity:	161/548 - (29%)
Similarity:	263/548 - (47%)	Gaps:	79/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILLFPGFLYGARILALFPVPSH--SHYYHALPYLKNLASLGHEITSVSP-----FPSEEPVKNIY 68
            ||:||                |  ||:.:....::.|...||:|:.:..     .|...|   .|
Zfish    54 ILVFP----------------HEGSHWLNLNTLIEELHHRGHQISVIRALDSWYIPETSP---HY 99

  Fly    69 D-IYVPEVLNSFDE-----LLKQMTTPK-NTWEFFDATNEFVYNITKDVFNNDGVRREIL----- 121
            | |.||.:|...|:     :.:|:...: ..|..|....|.     |:.|:.  :.|:|.
Zfish   100 DSINVPFLLGGDDQFYHSFIFRQLQIRREQRWTRFKLDMEL-----KEKFSE--MHRKICEMVIH 157

  Fly   122 ----RPG------KAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKID---EMVGNPSP 173
                .|.      :|.||:::.|........ ||.|...|::    ..:.|.:.   .....|||
Zfish   158 IVEKEPAIMKQIKEANFDIMLTDPANGGGVV-LAHYLHLPLV----FNVQWTVHGEAHFAIAPSP 217

  Fly   174 MSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYF-PKIAETKPLSEISQ 237
            .||:..|.|.|.:..:|..|:.:|:..|:..|.:.......:.||..:.| |.:    ...|:.|
Zfish   218 PSYVPFPLSQLTDSMSFPQRIYNVLFSAVRLFLYRRTVGPHYSALCNRLFGPGL----DYFELFQ 278

  Fly   238 DIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRT 302
            ...:.|:...|....|||.:||||.:||.|. ...|||.:|||||:|.|||||||..||||.|..
Zfish   279 AADIWLMRADFVFDFPRPTMPNVIYIGGFHC-SPAKALPKDLEDFLQSSGEHGVIVMSLGTLVAQ 342

  Fly   303 KNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQ 367
            ..|  |....::.||..|||:|:|::..:...::.:|.|:..||||.|||.|||.::|::|||..
Zfish   343 LPM--DIADEIVAAFAELPQKVIWRYTGDRPANVGNNTLLVNWLPQNDLLGHPKTRVFVSHGGTN 405

  Fly   368 STIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTAR 432
            ...|:|::|.|::|||..:||..|:..:|..|....|:...:..:..|..:.::|.:..:....:
Zfish   406 GVFEAIYHGVPIVGLPLVFDQDYNLLKMKHKGVAKVLDIATINRNIFKDALQEVLNDPSYRSNMQ 470

  Fly   433 IAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAI 497
            ...:.::|.|:|||::|::||.:|:||:||.|:|....|:.::::||:|| |..|       :::
Zfish   471 KLSSLHKDTPLKPLDSALFWTEFVMRHRGAAHLRTDSYKMPWYSYHSVDV-GVFL-------VSV 527

  Fly   498 LLIIVFSVCKISKNISTRLVVKKQRKQK 525
            |..|||.:.||.:.:..|...|..|.::
Zfish   528 LCFIVFLMFKIVRCLCCRFCAKTNRAKQ 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	141/482 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/481 (30%)
ugt5f1	XP_017207383.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584481
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790