DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5a4

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170969.2	Gene:	ugt5a4 / 100415798	ZFINID:	ZDB-GENE-100406-1	Length:	525	Species:	Danio rerio

Alignment Length:	556	Identity:	160/556 - (28%)
Similarity:	266/556 - (47%)	Gaps:	77/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSV-----------SPFP 59
            ||.|:.:|...  :..::|.: ||.. ||:.:....|..|.|.||.||.|           ||..
Zfish    10 LFLLLCVLSRS--HAGKLLVV-PVDG-SHWINMKVLLVELHSKGHSITVVRASNSWYIEEQSPLY 70

  Fly    60 SEEPVKN------IYDIYVPEVL------NSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFN 112
            :...|:|      ..:.::|.:|      .||   ..:|.....|:..|...::.:..:|..:|.
Zfish    71 TSITVENGEFDADFGEKFLPHLLKMQRQGKSF---WTEMALADETYSRFTEIHQEICKMTATMFE 132

  Fly   113 NDGVRREILRPGKAQFDLIIVDIWKYDAF---YSLAAYFEAPIIGLAPCGIDWKIDEMVGN---- 170
            |:.:...:   ..|.:|:::.|    .||   ..||.....|::    ..:.|   .|.|.
Zfish   133 NETLMNSL---KDAAYDVVLTD----PAFGGGVLLAHRLGLPLV----FNVRW---TMYGEAHFV 183

  Fly   171 --PSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYF-PKIAETKPL 232
              |||:||:......|.:..||..||.:::...:..:.....:...::.|.:||| |.:    ..
Zfish   184 IAPSPLSYVPVSGLQLTDKMTFSQRVMNMMTYIMILYKNSKYFGSPYQELTQKYFGPNV----NF 244

  Fly   233 SEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLG 297
            ..:.||..|.|:...||...|||.:|||:.:||... :..|.|..|||:|:|.|||||||..|||
Zfish   245 FSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQC-KPAKPLPGDLEEFVQSSGEHGVIMMSLG 308

  Fly   298 TNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFIT 362
            ...  ..::.:....:..||..|||:|:|::......::.:|.|:..||||.|||.|||.|||:.
Zfish   309 AVF--GQLLSELNDEIAAAFAQLPQKVIWRYTGPRPANLGNNSLIVNWLPQNDLLGHPKTKLFVA 371

  Fly   363 HGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRF 427
            |||.....|:|::|.|::|||..:||..|:..::..|....::.  .|.|  :|..|:.|.|...
Zfish   372 HGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVDI--ATLD--RAVFLEALKEVLH 432

  Fly   428 EVTARIAGAR----YRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLL 488
            ..:.|....|    :.|||||||:.|::|..:|:|:|||||:|....::|:..:.|:|    |:|
Zfish   433 NPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRTQSFRMSWIEYQSID----VIL 493

  Fly   489 VILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQ 524
            .::::::...|:..:    ::|....||..||.:::
Zfish   494 TLMVMVLVFALVTAY----MTKYFCLRLFRKKVKRE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	143/491 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	145/487 (30%)
ugt5a4	NP_001170969.2	UDPGT	23..525	CDD:278624	156/539 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000