DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	538	Identity:	152/538 - (28%)
Similarity:	272/538 - (50%)	Gaps:	64/538 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFYLIILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSV----SPFPSEEPVKN 66
            |:..::::|.....|.:|| :.|:.. ||:.:....:|.|...||.:..:    |.|..|.  ..
Zfish    13 LWITVMIIFGSLCDGGKIL-VAPLEG-SHWVNMDILIKALHGQGHTVDVIRNTNSWFVKEN--ST 73

  Fly    67 IYD-IYVPEVLNSFDELLKQMTTPKNTWE------------FFDA------TNEFVYNITKDVFN 112
            .|: |.:|:.....:|.::.:.|.|..:|            |.|.      :::.|..:..::|.
Zfish    74 YYNSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKLVCRLITNIFE 138

  Fly   113 NDGVRREILRPGKAQFDLIIVDI-WKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN------ 170
            ::.:.:.:   .:.::||::.|. |.....  ||...:.|::    ..:.|...   |.
Zfish   139 SEDILKAL---QEKKYDLMLTDPGWGTGII--LAHKLKLPMV----YNVRWTTP---GEGHFDIA 191

  Fly   171 PSPMSYLQSPSSYLYNLDTFGGRVAHV-----VEVAISWFNWHWRYEQKHEALYKKYF-PKIAET 229
            ||||||:....|...:..:|..||.:|     ::...|.||     ..:::||..||| |.:...
Zfish   192 PSPMSYIPLTGSGNTDKMSFFQRVINVFYYLLLDFQCSRFN-----VPQYQALCDKYFDPPVDFY 251

  Fly   230 KPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYF 294
            |.|    |...|.|:...|....|||.:||:|..||... ...|.|..|||||:|.||:||||..
Zfish   252 KLL----QGADLWLMRVDFVFEFPRPTMPNIIYTGGFQC-TPTKPLPHDLEDFMQSSGDHGVIVM 311

  Fly   295 SLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKL 359
            |||:.:..  :.|.....:..||..|||:|:|::..::...:.:|.|:..|:||:|||.|||.||
Zfish   312 SLGSFISV--LPDYVSSEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKL 374

  Fly   360 FITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTE 424
            ||.|||.....|::::|.|::|:|||:||:.|:..::..|....::..::..:.|.|.|.:::.|
Zfish   375 FIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQEVINE 439

  Fly   425 KRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLV 489
            ..:.:..:.....:||:|::||::|::|..:|:|||||.|:|....|:.::::||:||..|::.|
Zfish   440 PSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVTLIAV 504

  Fly   490 ILLVIIAILLIIVFSVCK 507
            :|:.|.::.:.:.:...|
Zfish   505 VLIFIYSMFVTVRYLCIK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	137/490 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	141/486 (29%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	149/523 (28%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	88/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585078
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690