DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	257/523 - (49%)	Gaps:	62/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LFPVPSHSHYYHALPYLKNLASLGHEIT-----------SVSPFPSEEPVKNIYDIYVPEVLNSF 79
            :||| ..||:.:....::.|.:.||.||           ..||..:...:|:...: ..:.:..|
Zfish    31 VFPV-DVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYTSVNLKSSGGL-SEDFIGPF 93

  Fly    80 DELLKQMTTPKNTW--------------EFFDATNEFVYNITKDVFNNDGVRREILRP-GKAQFD 129
            ...|..:....:||              :..:...|.:.|:.:|        :::::. .||:||
Zfish    94 VSRLMNILREGSTWGRLKLEIEMWQTSLKMIEIEREMITNMIED--------QQLMQSLKKAKFD 150

  Fly   130 LIIVDIWKYDAFYS---LAAYFEAPIIGLAPCGIDWKI---DEMVGNPSPMSYLQSPSSYLYNLD 188
            ||:.|    .|.|.   |..|.:.||:    ..:.|.|   ......|||:||:..|...:.:..
Zfish   151 LILTD----PAMYGGVMLGHYLKLPIV----YNVRWTIFGEGHFAIAPSPLSYVPVPMLEIPDRM 207

  Fly   189 TFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYF-PKIAETKPLSEISQDIALVLVNQHFTLGP 252
            :|..||.:||...|:.....:.....:.||.:::. |::    ....:.|:..|.|....|....
Zfish   208 SFLERVKNVVMYIITETQIAFLIAPTYNALCERFIGPEV----NFGNLVQEADLWLHRADFVFEY 268

  Fly   253 PRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAF 317
            |||.:||::.:.|... :..|.|.||||||:|.||:||||..||||.:  ..:.||....:.|||
Zfish   269 PRPTMPNIVYMAGFQC-KPSKPLPQDLEDFVQSSGDHGVIVMSLGTLI--GQLPDDVAEAIAEAF 330

  Fly   318 GSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGL 382
            ..|||:::|:::.:....:.:|.||..|:||.|||.|||.:.|:.|||.....|:|::|.|::|.
Zfish   331 AELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLGHPKTRAFVAHGGTNGVQEAIYHGVPIIGF 395

  Fly   383 PFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLE 447
            ...:||..|:..::..|...::::..|..:....|:.::|.:..:....:.....::|.|:|||:
Zfish   396 GLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLYDPSYRENMQRLSRLHKDVPVKPLD 460

  Fly   448 TAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKI---- 508
            .|::|..:|:|||||.|:|....|:.::::||:||:..::..:.|:|::|..:|.:..|:|
Zfish   461 NAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLIILSIYAVIRYFCCRICMRT 525

  Fly   509 SKN 511
            :||
Zfish   526 TKN 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	126/467 (27%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	133/483 (28%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	144/523 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584483
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790