DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	530	Identity:	141/530 - (26%)
Similarity:	249/530 - (46%)	Gaps:	71/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHYYHALPYLKNLASLGHEITSVSP-----FPSEEPVKNIYDIY-----VPEVLNSFDELLKQMT 87
            ||:.:....|..|...||.:|.:.|     ..::|..:..|..:     ..::.:.||||::
Zfish    30 SHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDRFSYQHFSVSKSAQDMQDFFDELMR--- 91

  Fly    88 TPKNTWEFFDATNEFVYNITKDVFN------------NDGVRR-----EILRPGKAQFDLIIVDI 135
                 :..|:..|.....|....||            .||:.:     :.|:.||  ||:::.|.
Zfish    92 -----FSVFEMDNSSFLEIQMKFFNLGSQHQDMSLSYCDGILKSPELMDKLKKGK--FDVVLSDP 149

  Fly   136 WKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN-PSPMSYLQSPSSYLYNLDTFGGRVAHVV- 198
             .|.....:|.....|::......:....:.|.|. |:|.||:....|.|.:..:|..|:.:::
Zfish   150 -MYPCSDIVAEELNVPLVYTFRFSVAHAAERMCGQIPAPPSYVPGAMSKLTDKMSFTERIFNMLF 213

  Fly   199 ---EVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNV 260
               :..:|...|     ::.:..|.:||   ..:....|:.....:.|:..::....|||:|||.
Zfish   214 YLSQDTLSRLIW-----RRFDNYYTEYF---GRSTSYCEMMGKADIWLIRTYWDFEFPRPFVPNF 270

  Fly   261 IEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVD----DRKRILIEAFGSLP 321
            ..:||:|. ...|.|.:|:|:|:|.||:.|::.|:||      :|:|    :....:..|...:|
Zfish   271 KYIGGLHC-TPAKPLPKDMEEFVQSSGDDGIVVFTLG------SMIDKVPKEMSNRIASALAQIP 328

  Fly   322 QRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFY 386
            |:|||::..|:...:..|..:.||:||.|||.|||.:.||||||.....|:|::|.||:|:|.|.
Zfish   329 QKVLWRYGGEKPDTLGENTRIYKWIPQNDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFG 393

  Fly   387 DQFTNVDHIKKHGFCLSL-NYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAV 450
            ||..|:.|:......:.: :...|...||...:..::.:..::..|......:.|:|||||:.:|
Zfish   394 DQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESV 458

  Fly   451 WWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTR 515
            :|..:|:|:|||.|:||....|:::.:|.|||     ...|..::.::|.|.|   |::|....|
Zfish   459 FWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDV-----FAFLTTVLTLVLYICF---KMAKFFIMR 515

  Fly   516 LVVKKQRKQK 525
            ...:.:||.|
Zfish   516 CCFRSKRKSK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	120/464 (26%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	131/487 (27%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	138/526 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860