DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	570	Identity:	161/570 - (28%)
Similarity:	269/570 - (47%)	Gaps:	92/570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASGLFYLIILLFPGFLYG--ARILALFPVP-SHSHYYHALPYLKNLASLGHEIT----SVSP-F 58
            :.||.. |:.||..|...|  .|:|.:   | .:||:::....::.|....|.:|    |.|| .
Zfish     1 MTSGAL-LVCLLLCGVDVGWSGRVLVM---PGEYSHWHNMRAIIEALVDRNHSVTVLVGSSSPTV 61

  Fly    59 PSEEPVKNIYDIY--------VPEVLNSF-----DELLKQMTTPKNTWE----FFDATNEFVYNI 106
            |..:..:..|.::        ...|.:.|     :|...:..|..|.::    |...|:|    :
Zfish    62 PHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVMSRFMTLTDE----V 122

  Fly   107 TKDVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYS---------LAAYFEAPIIGLAPCGIDW 162
            .|.:|..|.:  ::||..            .||..:|         :|.....|::........:
Zfish   123 CKGMFKEDLL--QMLRES------------HYDVLFSDPMMPCSDLMAQTLNIPLVLSLRATFAY 173

  Fly   163 KIDEMVGN-PSPMSYLQSPS--SYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKY-- 222
            ..:.|.|. |:|.||:.:.|  .:|.:..:|..|    ||..:.:|:        |:..:|.|
Zfish   174 SFERMCGQMPAPPSYVPAASLRDHLTDRMSFMER----VENMLLYFS--------HDVFFKLYMM 226

  Fly   223 --FPKI---AETKP--LSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLE 280
              |.:|   ...||  :.|......:.|:..::....|||:.||...|||:|. :..|.|::::|
Zfish   227 FTFDRIYTEIRGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEME 290

  Fly   281 DFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKW 345
            :|:|.||:|||:.||||:.:  ||:..:|...:..|.|.:||:|:|::..:..:.:..|..:..|
Zfish   291 EFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDW 353

  Fly   346 LPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMT 410
            :||.|||.|||.|.||||||.....|:|::|.||:|||.|.||..|:.|:|..|..:.|:.:.:.
Zfish   354 IPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLE 418

  Fly   411 SDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFF 475
            |.:|...:..:|....::.:.......:.|||||||:.||:|..:|:|:|||.|:||...:||::
Zfish   419 SKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWY 483

  Fly   476 THHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            .:|.|||     ...||.|.|::..:....|    ....|..|:|.|.::
Zfish   484 QYHCLDV-----AAFLLSIAALITFLWVKAC----CFLFRRCVRKTRPER 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	138/500 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	142/493 (29%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	152/542 (28%)
		REC	<129..>178	CDD:302758	8/62 (13%)
		egt	<254..485	CDD:223071	89/233 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55988
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930