DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E1 and ugt1b2

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001170807.1	Gene:	ugt1b2 / 100384893	ZFINID:	ZDB-GENE-080227-11	Length:	531	Species:	Danio rerio

Alignment Length:	553	Identity:	166/553 - (30%)
Similarity:	276/553 - (49%)	Gaps:	64/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIILLFPGFLYGARI-------------LALFPVPSHSHYYHALPYLKNLASLGHEITSVSP--- 57
            :|.:|..|.:..|.:             |.:.|:.. ||:.......:.:...||.:..|.|
Zfish     5 VIFILVVGVVCSAAVDQKPSRKSSWTGKLLVVPMDG-SHWTGVKAVAEEMGRRGHTVIVVIPEIS 68

  Fly    58 ---FPSEEPVKNIYDI-YVPEVLNS-FDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVR 117
               .|.:..:..::.: |..:.||. .:|.:.::|.|.|:  |.......|.|:.: :||.....
Zfish    69 VLLGPGQHYITKMFSVKYDQKSLNKVLNERVLEVTNPGNS--FLSTVIRIVSNLRR-MFNTMAAT 130

  Fly   118 REILRPGK--------AQFDLIIVD-IWKYDAFYSLAAYFEAPII----GLAPCGIDWKIDEMVG 169
            .|.|...|        ..||.::.| :....|.  ||.....|.:    |:| ||:|......
Zfish   131 SESLFQDKELIESLRNENFDAVLTDPVLPMGAI--LAYNLSVPAVYLLRGMA-CGLDATATTC-- 190

  Fly   170 NPSPMSYLQSPSSYLYNLD--TFGGRVAHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPL 232
             |:|.||:  |..:..|.|  :||.||.:::...:......:.|....|.:    |..:.....:
Zfish   191 -PNPSSYI--PRFHTRNTDRMSFGERVMNMLMSILEQTVCKFMYRSFEEMI----FNFLQRDVSM 248

  Fly   233 SEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLG 297
            :||.:..|:.|:...|||..|:|.:||:..:||::...: ..|.:::|:|:.||||||::.||||
Zfish   249 TEILRTGAVWLMRYDFTLEFPKPLMPNMQFIGGINCGVR-NPLTKEVEEFVNGSGEHGIVVFSLG 312

  Fly   298 TNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFIT 362
            :.|  .:|..::..|..:||..:||||||::..|...::|.||.:.|||||.|||.|||.:.|||
Zfish   313 SLV--SSMPKEKADIFFKAFSMIPQRVLWRYTGEIPNNVPENVKLMKWLPQNDLLGHPKARAFIT 375

  Fly   363 HGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRF 427
            |||.....|.|.:|.||:.||.|.||..||..:...|..:.|:.||:|.:.|...:..::....:
Zfish   376 HGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATRGVGVILSIHDITVETLLDALNSVINNSSY 440

  Fly   428 EVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILL 492
            :...:...|.:.|:|::||:.||:||.:|:|||||.|:|.|..:|::..:|||||:|.:||::|:
Zfish   441 KQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLRPAAHELNWLQYHSLDVIGFMLLIVLI 505

  Fly   493 VIIAILLIIVFSVCKISKNISTRLVVKKQRKQK 525
            |.:|:|     ..|    ::..|...:|.:|:|
Zfish   506 VTLAML-----KCC----SLCWRRCCRKTQKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	142/487 (29%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	148/473 (31%)
ugt1b2	NP_001170807.1	UDPGT	31..527	CDD:278624	160/523 (31%)
ugt1b2	NP_001170807.1	egt	<271..510	CDD:223071	97/241 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584676
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830