DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E1 and ugt1a6

DIOPT Version :9

Sequence 1:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001107366.1	Gene:	ugt1a6 / 100135191	XenbaseID:	XB-GENE-5793241	Length:	531	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	159/545 - (29%)
Similarity:	256/545 - (46%)	Gaps:	57/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FYLIILLFPGFLYGARILALFPVPSH-SHYYHALPYLKNLASLGHEITSVSP-----FPSEE--P 63
            |::::.|  |...|.|:|.   ||.. ||:......:..||..||.|....|     |...:  .
Frog    16 FFILLAL--GCADGGRLLV---VPQDGSHWLSMRVLVDRLAQRGHYIVVAIPEVNMLFKDLDNYK 75

  Fly    64 VKNIYDIYVPEVLNSFDELLKQ------MTTPKNTWEFFDATN--EFVYNITKDVFNNDGVRREI 120
            ||.....|..:||.:....:.|      :.|.|.|:.:...:|  ::|.:..:....|..:.||:
Frog    76 VKTFSSPYSKDVLENRMRRMNQEIFVDRILTEKITFWYESMSNATQWVVSACQHFLQNSTLIREL 140

  Fly   121 LRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVG-NPSPMSYLQSPSSYL 184
               .|..||.::.|. .:.....:|.:...|.:.... |..:.:|::.. .|||.||:  |..:.
Frog   141 ---EKEHFDAMLTDS-VFPCGEIVAEHLSIPSVSFMR-GTIFGMDQIASQTPSPPSYV--PRMFT 198

  Fly   185 YNLD--TFGGRV----AHVVEVAISWFNWHWRYEQKHEALYKKYFPKIAETKPLSEISQDIALVL 243
            ...|  :|..||    .|.:|..:... :::.|.|......||      |...:|..|: .::.|
Frog   199 VYTDNMSFSQRVKNFLIHSLEHIVCHI-FYYPYAQMASDFLKK------EVTAMSLFSR-TSIWL 255

  Fly   244 VNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVR--TKNMV 306
            :...|....|||.:||||.:||::..:| |||.|:.|..::.|||||.:.||.|:.|.  ..|:.
Frog   256 MRYDFVFEFPRPIMPNVILIGGINCAKQ-KALPQEFEKLVKSSGEHGFVVFSFGSMVSEIPMNIA 319

  Fly   307 DDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIE 371
            .|    :.||...:||:|.|::..:...::..|..:.|||||.|||||||.:.||||.|.....|
Frog   320 MD----IAEALRYIPQKVFWRYTGKAPPNLGDNTHLVKWLPQNDLLAHPKARAFITHAGSHGVYE 380

  Fly   372 SIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGA 436
            .|....||:.||...||..|...|:..|..|.||..::..|:|...::.::....::...:...:
Frog   381 GICNAVPMVMLPLIGDQMDNAKRIESRGAGLILNVQNLIPDDLSNAVMAVIDNPSYKENIQRLSS 445

  Fly   437 RYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVIIAILLII 501
            .:||:|::||:.||.|..:|::||||||:|.|...|::..:.||||:..:|.|:|..:...|...
Frog   446 LHRDRPVQPLDLAVHWVEFVMKHKGAPHLRPAAHDLNWIQYQSLDVMAFLLAVLLTTLFISLKCS 510

  Fly   502 VFSV-CKISKNISTRLVVKKQRKQK 525
            .|:. |...:|      .|.:||.|
Frog   511 TFACRCCCKRN------TKPKRKTK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	136/478 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	140/474 (30%)
ugt1a6	NP_001107366.1	UDPGT	28..527	CDD:278624	152/527 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9349
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960