DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_444414.2	Gene:	Ugt2a1 / 94215	MGIID:	2149905	Length:	528	Species:	Mus musculus

Alignment Length:	497	Identity:	122/497 - (24%)
Similarity:	238/497 - (47%)	Gaps:	52/497 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GSSYLLITPFLRNLVQRGHQLTL--------ISAVTIMPHIE-GVHHIRVPKLDMLMKILLDF-- 92
            ||.:|.:...:..|:::.|.:|:        |:..:|.|.:. .::.:...| :.:..::.||
Mouse    30 GSHWLNVKIIIDELLRKEHNVTVLVASGALFITPSSISPSLTFEIYPVPFGK-EKIESVIKDFVL 93

  Fly    93 ----EYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQE-LLRN-------ASAKYSLIILEASHN 145
                ...:..|.||   |..|......:|.|...|:.: :|:|       ...|:.:::     :
Mouse    94 TWLENRPSPSTIWT---FYKEMAKVIEEFHLVSRGICDGVLKNEKLMSKLQKEKFEVLL-----S 150

  Fly   146 DALYG----FSQHFNAPLLGVAAYGSSWNIDFLVGN-SAPSVYEPMSALGYTSGLNLIEKWHNLI 205
            |.::.    .:.....|.:....:..:..::...|. ..|..|.|......|..::..::..|.|
Mouse   151 DPVFPCGDIVALKLGIPFIYSLRFSPASTVEKHCGKVPFPPSYVPAILSELTDQMSFTDRVRNFI 215

  Fly   206 -YITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVA 269
             |..::.:.|.   |.:|.|.|.....|..|::.:...:..:.|:..::.....|..:||...|.
Mouse   216 SYRMQDYMFET---LWKQWDSYYTKALGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVG 277

  Fly   270 GMHLDEKP-YPLDAELKKILD-EAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIW-- 330
            |:|.  || .||..|:::.:. ..|||::.||:|..:.:  |.......::.|.||:.|:|:|
Mouse   278 GLHC--KPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVKN--LTDEKANLIASALAQIPQKVLWRY 338

  Fly   331 KTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQN 395
            |...|:.:..:..:|  .|.||..:|.||..:.||||.|...:.|::::.:|::.:|:|.||..|
Mouse   339 KGKIPDTLGSNTRLF--DWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDN 401

  Fly   396 TKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYI 460
            ...|:..|.|.:::...:...:::.|:..::...|||.||..||:..||||:..:|.|::|.|::
Mouse   402 IAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFV 466

  Fly   461 LRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVI 502
            :|||||.|:|:|..::|..||:::||:..|...:. |||:::
Mouse   467 MRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACVA-SAILLV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	107/458 (23%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	122/497 (25%)
Ugt2a1	NP_444414.2	UDPGT	21..516	CDD:278624	122/497 (25%)
Ugt2a1	NP_444414.2	egt	<267..487	CDD:223071	73/225 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840252
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.690