DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	139/560 - (24%)
Similarity:	245/560 - (43%)	Gaps:	113/560 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GPGIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI---SAV 65
            |..|:.|||..:.|   |.|..|...:| |:...: |.::.|...|..|||:||::|::   ::|
  Rat     3 GKWISALLLLQISF---CFKSGNCGKVL-VWPMEY-SHWMNIKIILEELVQKGHEVTVLRPSASV 62

  Fly    66 TIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELLRN 130
            .:.|                 |...|.::.|..|.:: :..|..:|   ::||  :....||.|:
  Rat    63 FLDP-----------------KETSDLKFVTFPTSFS-SHDLENFF---TRFV--NVWTYELPRD 104

  Fly   131 ASAKYSLII---------------------------LEASHNDALYG---------FSQHFNAPL 159
            ....|.|.:                           |:.|..|.::.         .::....|.
  Rat   105 TCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAIGPCGELIAELLQIPF 169

  Fly   160 LGVAAYGSSWNIDFLVGNSA-PSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQI 223
            |....:...:.|:..:|... |..|.||...|....:..||:.||:|.:         :|    .
  Rat   170 LYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGLAGQMTFIERVHNMICM---------LY----F 221

  Fly   224 DLYKQHFP------------GATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-DE 275
            |.:.|.|.            |..|::.::..:..:.||..::.:.......||:..:.|:|. ..
  Rat   222 DFWFQTFREKKWDPFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHCKPA 286

  Fly   276 KPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSD--------AFAQLKQQVIWKT 332
            ||.|.|.| ..:....||||:.||:|          .|..:|::        |.||:.|:|:|:.
  Rat   287 KPLPKDIE-DFVQSSGEHGVVVFSLG----------SMVRNMTEEKANIIAWALAQIPQKVLWRF 340

  Fly   333 DYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTK 397
            |..:......|.....|.||..:|.||..|.|:||.|...:.|::|:.:|::.||||.:|..|..
  Rat   341 DGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIA 405

  Fly   398 RMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILR 462
            .|...|.|.:::|:.:.:.:::.|:|:::.|..||:||..||...||||...:|.|::|.|:::|
  Rat   406 HMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMR 470

  Fly   463 HKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVI 502
            ||||.|:|.....:...||:::||:..|...:.::.::.:
  Rat   471 HKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTVVLAL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	121/499 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	128/525 (24%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	130/536 (24%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	74/229 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.690