Protein Alignment Ugt303A1 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_001262470.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 128/531 - (24%)
• Similarity: 239/531 - (45%)
• Gaps: 83/531 - (15%)

  Fly    40 SSYLLITPFLRNLVQRGHQLTLI--SAVTIMPH-------IEGVHHIRVPK---------LDMLM 86
            |.:|.:...|..|:.|||::|::  |..:::.:       .|.||   :|:         :|:.:
Human    34 SHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVH---MPQDRTEENEIFVDLAL 95

  Fly    87 KILLDFEYDTDLTKWTEAQFLSEYFYN--------CSKFVLEDPGVQELLRNASAKYSLIILE-- 141
            .:|      ..|:.|.....|:::|..        |..|:.....:::|   ....|.:::::
Human    96 NVL------PGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKL---QETNYDVMLIDPV 151

  Fly   142 ASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGN-SAPSVYEPMSALGYTSGLNLIEKWHNLI 205
            ....|.:   ::....|.:.........|::...|. .||..|.|:...|.|..:..:|:
Human   152 IPCGDLM---AELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLER----- 208

  Fly   206 YITEERLVERFIYLPRQIDLYKQHF--------PGATTSIHDLRRRFSLVLINQHFTMGRVRSNV 262
             :....|...|.:   .|..|..||        .|..|::.:...:..:.||..::.....:...
Human   209 -VKNSMLSVLFHF---WIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQ 269

  Fly   263 PNIVEVAGMHLDEKPYPLDAELKKILDEAEH--------GVIYFSMGLQLLDHWLPPGMRASMSD 319
            ||...|.|:|.  ||.....::...|.|.|:        |::.||:| .|..: :.......::.
Human   270 PNFEFVGGLHC--KPAKALPKINFYLQEMENFVQSSGEDGIVVFSLG-SLFQN-VTEEKANIIAS 330

  Fly   320 AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLL 384
            |.||:.|:|:|:....:......|.....|.||..:|.||..|.||||.|:..:.|::::.||::
Human   331 ALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMV 395

  Fly   385 CIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSA 449
            .:|:|.||..|...|:..|.|.:::||.:..::::.|:..::.::|||.||..||:..||||:..
Human   396 GVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKP 460

  Fly   450 MDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLA-- 512
            :|.|::|.|:::|||||.|:|.|..:::..|:|::||:..|...:..:    |||..|....:
Human   461 LDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATA----IFLFTKCFLFSCQ 521

  Fly   513 ----TRHLEYR 519
                ||.:|.|
Human   522 KFNKTRKIEKR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	109/469 (23%)
		UDPGT	39..507	CDD:278624	123/511 (24%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	125/525 (24%)
		egt	<267..498	CDD:223071	74/234 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690