Protein Alignment Ugt303A1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 128/531 - (24%)
• Similarity: 239/531 - (45%)
• Gaps: 83/531 - (15%)

  Fly    40 SSYLLITPFLRNLVQRGHQLTLI--SAVTIMPH-------IEGVHHIRVPK---------LDMLM 86
            |.:|.:...|..|:.|||::|::  |..:::.:       .|.||   :|:         :|:.:
Human    34 SHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVH---MPQDRTEENEIFVDLAL 95

  Fly    87 KILLDFEYDTDLTKWTEAQFLSEYFYN--------CSKFVLEDPGVQELLRNASAKYSLIILE-- 141
            .:|      ..|:.|.....|:::|..        |..|:.....:::|   ....|.:::::
Human    96 NVL------PGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKL---QETNYDVMLIDPV 151

  Fly   142 ASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGN-SAPSVYEPMSALGYTSGLNLIEKWHNLI 205
            ....|.:   ::....|.:.........|::...|. .||..|.|:...|.|..:..:|:
Human   152 IPCGDLM---AELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLER----- 208

  Fly   206 YITEERLVERFIYLPRQIDLYKQHF--------PGATTSIHDLRRRFSLVLINQHFTMGRVRSNV 262
             :....|...|.:   .|..|..||        .|..|::.:...:..:.||..::.....:...
Human   209 -VKNSMLSVLFHF---WIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQ 269

  Fly   263 PNIVEVAGMHLDEKPYPLDAELKKILDEAEH--------GVIYFSMGLQLLDHWLPPGMRASMSD 319
            ||...|.|:|.  ||.....::...|.|.|:        |::.||:| .|..: :.......::.
Human   270 PNFEFVGGLHC--KPAKALPKINFYLQEMENFVQSSGEDGIVVFSLG-SLFQN-VTEEKANIIAS 330

  Fly   320 AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLL 384
            |.||:.|:|:|:....:......|.....|.||..:|.||..|.||||.|:..:.|::::.||::
Human   331 ALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMV 395

  Fly   385 CIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSA 449
            .:|:|.||..|...|:..|.|.:::||.:..::::.|:..::.::|||.||..||:..||||:..
Human   396 GVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKP 460

  Fly   450 MDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLA-- 512
            :|.|::|.|:::|||||.|:|.|..:::..|:|::||:..|...:..:    |||..|....:
Human   461 LDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATA----IFLFTKCFLFSCQ 521

  Fly   513 ----TRHLEYR 519
                ||.:|.|
Human   522 KFNKTRKIEKR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	109/469 (23%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	125/525 (24%)