DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	503	Identity:	144/503 - (28%)
Similarity:	243/503 - (48%)	Gaps:	78/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PFLRNLVQRGHQLTLI--SAVTIMPHIEGVH-HIRVPKLDMLMKILLDF---------------E 93
            |.:..||.:.|.:|::  |:...:||.:... ...|.|::| .|.::|:               .
Zfish    38 PVIEALVDKNHSVTVLVGSSSPTVPHTQKERFEYHVFKVNM-EKEVVDYLWIHFHELWMNETIST 101

  Fly    94 YDTDLTKWTEAQFLSEYFYNCSKFV--LEDPGVQELLRNASAKYSLIILEASHNDALYGFS---- 152
            |:..|..|   |.:|.:..:..:.|  |.|.|:.:.||:::  |.::.     :|....||
Zfish   102 YEKTLEVW---QLMSLFRAHSEELVKGLFDVGLLKTLRDSN--YDVLF-----SDLTMPFSDLMA 156

  Fly   153 QHFNAPLLGVAAYGSSWNIDF------LVGN-SAPSVYEPMS-ALGY-TSGLNLIEKWHN-LIYI 207
            |..|.|      :..|..|.|      |.|. ..|..|.|.: |.|: |..::..|:..| |:||
Zfish   157 QKLNIP------HVLSMRISFASALERLCGQMPVPQSYVPAAVAQGHLTDRMSFTERVENMLLYI 215

  Fly   208 TEE---RLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVA 269
            |..   :|..:|.:     |.......|..|::.:...:..:.||..::.....|...||...|.
Zfish   216 THTAMFQLTTKFTF-----DHIYAEISGEPTTMCETIGKTDIWLIRTYWDFEYPRPFPPNFKFVG 275

  Fly   270 GMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIW-- 330
            |:..  || .||..||::.:..: :||::.||:|..:.:  |......:::.|..|:.|:|:|
Zfish   276 GLQC--KPAKPLAKELEEFVQSSGDHGIVVFSLGSMIKN--LTVQKANTIAAALGQISQKVVWRY 336

  Fly   331 --KTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQF 393
              ||  ||.:..:..::  .|.||..:|.||..|.||||.|...|.|::::.||::.:|||.||.
Zfish   337 SGKT--PETLAPNTKIY--DWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQP 397

  Fly   394 QNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTE 458
            .|...::..|.|..|||..|...::|.|::.::.|.|||.:...||:..|||||..:|.|::|.|
Zfish   398 DNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIE 462

  Fly   459 YILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGW 506
            :::|:|||.|:|:...|:|..||:.:||.:.|   :.::|:|. || |
Zfish   463 FVMRNKGAKHLRVQAHELSWYQYHCLDVAAFL---LSITALIT-FL-W 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	127/460 (28%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	144/503 (29%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	144/503 (29%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	81/238 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830