DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	539	Identity:	144/539 - (26%)
Similarity:	241/539 - (44%)	Gaps:	91/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI---------------SAV 65
            ||.|||....:....|.|.... ||.::.:...:..|..|||.:|::               :::
Zfish     9 LFLLLCVLSRSYAGKLLVVPVE-GSHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPLYTSI 72

  Fly    66 TI-------------MPHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFY----- 112
            |:             :||              |:||....:     :.|.|.....|..:
Zfish    73 TVDNGVFDDDFMEKFLPH--------------LLKIQRQGK-----SFWNEMALADEMIHFVTET 118

  Fly   113 -----NCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYG----FSQHFNAPLLGVAAYGSS 168
                 |.:..:.|:..:...|::|:  |.:::     .|..||    .:.....||:    |...
Zfish   119 HKQSCNMTAILFENETLMNSLKDAA--YDVVL-----TDPAYGSGVLLAHRLGLPLV----YNVR 172

  Fly   169 WNI----DFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLI-YITEERLVERFIYLPRQIDLYKQ 228
            |.:    .|.:..| |..|.|:|.|..|..:...::..|:: ||.......:....|.| :|.::
Zfish   173 WTVYGEAHFDIAPS-PLSYVPVSGLQLTDKMTFSQRVMNMMTYIMIRYKYSKNFGSPYQ-ELTQK 235

  Fly   229 HFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-DEKPYPLDAELKKILDEAE 292
            :| |...:...|.:...|.|:...||....|..:||:|.:.|... ..||.|.|.| :.:....|
Zfish   236 YF-GPNVNFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLE-EFVQSSGE 298

  Fly   293 HGVIYFSMGL---QLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRA 354
            ||||..|:|.   |||..     :...::.|||||.|:|||:...|...|...|.....|.||..
Zfish   299 HGVIMMSLGTVFGQLLSE-----LNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQND 358

  Fly   355 ILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIV 419
            :|.||..|||:.|.|...|.|::::.||::.:||.:||..|..||...|.|:.::|..|.|...:
Zfish   359 LLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFL 423

  Fly   420 LAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNV 484
            .|::::::|.||:.|.:.||:..|||||..:|.||:|.|:::|:|||.|:|.....||.::|.::
Zfish   424 EALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSI 488

  Fly   485 DVVSVLFGRIGLSAIIVIF 503
            ||:..|...:.:..::.::
Zfish   489 DVILTLMLMVLVFVLLTVY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	128/489 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	137/516 (27%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	139/526 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690