DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT8

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	246/523 - (47%)	Gaps:	48/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEG-----VHHI---RVP 80
            :..|..|:.|....|.|...:.......|.:|||.       |:....||     .:|.   |.|
Human    17 IAKAAKIIIVPPIMFESHMYIFKTLASALHERGHH-------TVFLLSEGRDIAPSNHYSLQRYP 74

  Fly    81 KL------DMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELLRNASAKYSLII 139
            .:      |..::..:...:...||.......|..|..||...|.....:|.|.:.   |:.|::
Human    75 GIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKE---KFDLLL 136

  Fly   140 LEASHNDALYGFSQHFNAPLLGV--AAYGSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWH 202
            ::.  || :.||   ..|.||||  |.:.:.......||..||..|.|......|..:||:::..
Human   137 VDP--ND-MCGF---VIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMK 195

  Fly   203 NL-IYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIV 266
            |. :|:. .||...|:.||:...:.:::......|::||....||.::.....:...|..:||:|
Human   196 NTGVYLI-SRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVV 259

  Fly   267 EVAGMHLDEKPYPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIW 330
            .|.|: |.:...||..:|::.::.| |||.:..|.|..:  .:|...:...::.|..:|.|:|||
Human   260 YVGGI-LTKPASPLPEDLQRWVNGANEHGFVLVSFGAGV--KYLSEDIANKLAGALGRLPQKVIW 321

  Fly   331 KTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQN 395
            :...|:..|...|.....|.||..:|.|..:|.|::|.||.|:.|::::.||::.||||.|.:..
Human   322 RFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDT 386

  Fly   396 TKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYI 460
            ..|::..|:...|::|.:...|:..|:..::.|.||::.|:.||:...|||...::..|:|.:||
Human   387 MTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYI 451

  Fly   461 LRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGW-------KLVSLATRHLEY 518
            :||.||.|:|.|..::|..||:.:|:..||.  :| :|::...|.|       |:.||.:|:...
Human   452 IRHNGAHHLRAAVHQISFCQYFLLDIAFVLL--LG-AALLYFLLSWVTKFIYRKIKSLWSRNKHS 513

  Fly   519 RLN 521
            .:|
Human   514 TVN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	124/456 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	135/492 (27%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	138/503 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740