Protein Alignment Ugt303A1 and UGT2B17

DIOPT Version :9

• Sequence 1: NP_001262470.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 139/529 - (26%)
• Similarity: 246/529 - (46%)
• Gaps: 94/529 - (17%)

  Fly    40 SSYLLITPFLRNLVQRGHQ-LTLISAVTIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLTK--- 100
            |.::.:...|..||||||: :.|.|:.:|:.:......|   ||::         |.|.|||
Human    34 SHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAI---KLEV---------YPTSLTKNDL 86

  Fly   101 ----------WT----EAQFLSEYF------------YN---CSKFVLEDPGVQELLRN-ASAKY 135
                      ||    :..|.| ||            ||   |...||.    ::|:|. ..:|:
Human    87 EDFFMKMFDRWTYSISKNTFWS-YFSQLQELCWEYSDYNIKLCEDAVLN----KKLMRKLQESKF 146

  Fly   136 SLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLV-----GNSAPSVYEPMSALGYTSGL 195
            .:::.:|. |......::..|.|.|    |...:::.:.|     |...|..|.|:.....:..:
Human   147 DVLLADAV-NPCGELLAELLNIPFL----YSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQM 206

  Fly   196 NLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFP---GATTSIHDLRRRFSLVLINQHFTMGR 257
            ..:|:..|:||:    |...|.:....:..:.|.:.   |..|::.:...:..:.||..::....
Human   207 IFMERIKNMIYM----LYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEF 267

  Fly   258 VRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSD- 319
            .|..:||:..|.|:|.  || .||..|:::.:..: |:|::.||:|          .|.::||:
Human   268 PRPFLPNVDFVGGLHC--KPAKPLPKEMEEFVQSSGENGIVVFSLG----------SMISNMSEE 320

  Fly   320 -------AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESV 377
                   |.||:.|:|:|:.|..:......|.....|.||..:|.||..|.||||.|...:.|::
Human   321 SANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAI 385

  Fly   378 HYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRF 442
            ::.:|::.||||.||..|...|:..|.|..:|.:.:...:::.|::.::.:..||.|...||:..
Human   386 YHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIH 450

  Fly   443 HDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWK 507
            ||||:..:|.|::|.|:::|||||.|:|:|...::.:||:::||::.|...:.    .:||:..|
Human   451 HDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVA----TMIFMITK 511

  Fly   508 LVSLATRHL 516
            ......|.|
Human   512 CCLFCFRKL 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	123/476 (26%)
		UDPGT	39..507	CDD:278624	136/518 (26%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	137/525 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690