DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	516	Identity:	138/516 - (26%)
Similarity:	255/516 - (49%)	Gaps:	68/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SSYLLITPFLRNLVQRGHQLTLI--SAVTIMPHIEG------VHHIRVPK---LDMLMKILLDFE 93
            |.::.:...|..||||||::|::  ||.|::...:.      |:...:.|   .|.|:|||..:.
Human    34 SHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWI 98

  Fly    94 Y----DTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQE--LLRNASAKYSLIILEASHNDALYGFS 152
            |    :|..:.:::.|.|...:|:.|..:.:|..:.:  :::...:|:.:|:.:|. |......:
Human    99 YGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADAL-NPCGELLA 162

  Fly   153 QHFNAPLLGVAAYGSSWNIDFLVGNS---------APSVYEPMSALGYTSGLNLIEKWHNLIYIT 208
            :.||.|.|        :::.|.||.:         .|..|.|:.....:..:..:|:..|:|::
Human   163 ELFNIPFL--------YSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHM- 218

  Fly   209 EERLVERF---IYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAG 270
               |...|   ||..::.|.:.....|..|::.:...:..:.||..::.....|..:||:..|.|
Human   219 ---LYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGG 280

  Fly   271 MHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPPGMRASMSD--------AFAQLK 325
            :|.  || .||..|:::.:..: |:|::.||:|          .|.::||:        |.||:.
Human   281 LHC--KPAKPLPKEMEEFVQSSGENGIVVFSLG----------SMISNMSEESANMIASALAQIP 333

  Fly   326 QQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFY 390
            |:|:|:.|..:......|.....|.||..:|.||..|.||||.|...:.|::::.:|::.||||.
Human   334 QKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFA 398

  Fly   391 DQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIW 455
            ||..|...|:..|.|..:|.:.:...:::.|::.::.:..||.|...||:..|||||..:|.|::
Human   399 DQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVF 463

  Fly   456 WTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATRHL 516
            |.|:::|||||.|:|:|...::.:||:::||::.|...:.    .|||:..|......|.|
Human   464 WIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVA----TVIFIITKFCLFCFRKL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	121/463 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	135/505 (27%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	134/502 (27%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	136/512 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690