Protein Alignment Ugt303A1 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 145/552 - (26%)
• Similarity: 259/552 - (46%)
• Gaps: 82/552 - (14%)

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLT-LISAVTIMPHIEG 73
            :||..|.|   |....|...:| |::..: |.::.|...|..|:||||::| |.|:.:|:..
Human     9 ILLIQLSF---CFSSGNCGKVL-VWAAEY-SHWMNIKTILDELIQRGHEVTVLASSASILFD--- 65

  Fly    74 VHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCS-----KFVLEDPGVQELLR---- 129
                  |.....:||.:   |.|.|||.....|:.:.....|     .|.|....|||::.
Human    66 ------PNNSSALKIEI---YPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFGD 121

  Fly   130 ---------NASAKYSLIILEASHN----DALYGFS----QHFNAPLLGVAAYGSSWNIDFLVGN 177
                     .::.|:...:.|:..:    ||::..|    :.||.|.:...::...:..:...|.
Human   122 ITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTFEKHSGG 186

  Fly   178 SA-PSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERF---IYLPRQIDLYKQHFPGATTSIH 238
            .. |..|.|:.....|..:..:|:..|:||:    |...|   |:..::.|.:.....|..|::.
Human   187 FIFPPSYVPVVMSELTDQMTFMERVKNMIYV----LYFDFWFEIFDMKKWDQFYSEVLGRPTTLS 247

  Fly   239 DLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMG 301
            :...:..:.||...:........:||:..|.|:|.  || .||..|::..:..: |:||:.||:|
Human   248 ETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHC--KPAKPLPKEMEDFVQSSGENGVVVFSLG 310

  Fly   302 LQLLDHWLPPGMRASMSD--------AFAQLKQQVIWKTD--YPEMVNQSRNVFARTWFPQRAIL 356
                      .|.::|::        |.||:.|:|:|:.|  .|:.:..:..::  .|.||..:|
Human   311 ----------SMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLY--KWIPQNDLL 363

  Fly   357 NHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLA 421
            .||..:.||||.|...:.|::::.:|::.||||.||..|...|:..|.|.::||..:...:::.|
Human   364 GHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNA 428

  Fly   422 IEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDV 486
            ::.::.:.|||.|...||:..||||:..:|.|::|.|:::|||||.|:|:|..:::..||:::||
Human   429 LKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDV 493

  Fly   487 VSVLFGRIGLSAIIV----IFLGWKLVSLATR 514
            :..|...:.....||    :|..||....|.:
Human   494 IGFLLVCVATVIFIVTKCCLFCFWKFARKAKK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	123/481 (26%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	139/532 (26%)