Protein Alignment Ugt303A1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 135/529 - (25%)
• Similarity: 265/529 - (50%)
• Gaps: 51/529 - (9%)

  Fly    14 VLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI---SAVTIMPHIEG-- 73
            :||..|.|...:.:...:.|:...| |.::.|...|..||||||::|::   ::::..|:...
Human     9 LLLIQLSCYFSSGSCGKVLVWPTEF-SHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTL 72

  Fly    74 ---VHHIRVPK------LDMLMKILLDFEYDTDLTKWTEAQFLSEYFYN-CSKFVLEDPGVQELL 128
               |:.:.:.|      :..|:|...:...||..:.:::.|.:...|.: ..||..:....::|:
Human    73 KFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLM 137

  Fly   129 RN-ASAKYSLIILEASHNDALYGFSQHFNAPLLGVA-AYGSSWNIDFLV-----GNSAPSVYEPM 186
            :. ..:::.:::.     ||::.|.: ..|.||.:. .|...::..:.:     |...|..|.|:
Human   138 KKLQESRFDVVLA-----DAVFPFGE-LLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPV 196

  Fly   187 SALGYTSGLNLIEKWHNLIYITEERLVERF---IYLPRQIDLYKQHFPGATTSIHDLRRRFSLVL 248
            .....:..:..||:..|:||:    |...|   |:..::.|.:.....|..|::.:...:..:.|
Human   197 VMSELSDQMTFIERVKNMIYV----LYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWL 257

  Fly   249 INQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILDEA-EHGVIYFSMGLQLLDHWLPP 311
            |..::........:||:..|.|:|.  || .||..|:::.:..: |:||:.||:|..:.:   ..
Human   258 IRNYWDFQFPHPLLPNVEFVGGLHC--KPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSN---TS 317

  Fly   312 GMRAS-MSDAFAQLKQQVIWKTD--YPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSL 373
            ..||: ::.|.|::.|:|:|:.|  .|:.:..:..::  .|.||..:|.||..:.||||.|...:
Human   318 EERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLY--KWIPQNDLLGHPKTRAFITHGGANGI 380

  Fly   374 IESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDL 438
            .|::::.:|::.:|||.||..|...|:..|.|..|||..:...:::.|::.::.:..||.||..|
Human   381 YEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKL 445

  Fly   439 SQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIV-- 501
            |:..||||:..:|.|::|.|:::|||||.|:|:|..:::..||:::||...|...:.....|:
Human   446 SRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITK 510

  Fly   502 -IFLGWKLV 509
             :|..||.|
Human   511 CLFCVWKFV 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	115/468 (25%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	131/514 (25%)