DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	525	Identity:	148/525 - (28%)
Similarity:	251/525 - (47%)	Gaps:	88/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFGLLCPKLTNAENILAVFSYTFGSSYLLITP-----------FLRNLVQRGHQLTLI------- 62
            ||.|||           |.|.|:|.. :|:.|           .:..|.::||.:|::
Zfish     9 LFSLLC-----------VLSGTYGGK-VLVFPLDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWY 61

  Fly    63 --------SAVTIMPHIEG------------VHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFL 107
                    |::|| |:..|            :..|:.....:|.::.|:||.   :.|:   :.:
Zfish    62 IKEESPFYSSITI-PNTGGFDEEFSGLLINRLLEIKRGGYFVLNRVRLEFEI---MMKF---KTM 119

  Fly   108 SEYFYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYG---FSQHFNAPLLGVAAYGSSW 169
            .|........:|||..|...:::  ||:.:::.:    .|:.|   .:..||.||:    :...|
Zfish   120 HEDMLQMMDRMLEDEKVMNSIQD--AKFDVVLAD----PAVGGGPILAYKFNIPLV----FNVRW 174

  Fly   170 NID----FLVGNSAPSVYEPMSALGYTSGLNLIEKWHN-LIYITEE---RLVERFIYLPRQIDLY 226
            .|.    |.:..| |..|.|:..:..|..::.:::..| |||:..:   :::...||.|    ..
Zfish   175 TIQGEGHFAIAPS-PLSYIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAP----FC 234

  Fly   227 KQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-DEKPYPLDAELKKILDE 290
            .:|| |...:...|.:...:.|:...||....|..:||||.::|... ..||.|.|.| |.:...
Zfish   235 HKHF-GPNVTYFSLFQDADIWLMRNDFTFEFPRPTMPNIVYMSGFQCKPAKPLPNDLE-KFVESS 297

  Fly   291 AEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAI 355
            .|||||..|:|..:..  ||..|...::.|||:|.|:|||:...|..|....|.....|.||..:
Zfish   298 GEHGVIVMSLGTLIAQ--LPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDL 360

  Fly   356 LNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVL 420
            |.||.:|:|:.|.|...:.|::::.||:|.:||.:||..|..|||..|.|:.:|...|.:...:.
Zfish   361 LGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLE 425

  Fly   421 AIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVD 485
            |:::::||.||:.|.:.||:..||||:..:|.|::|.|:::|:|||.|:|.....||.::|:::|
Zfish   426 ALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSID 490

  Fly   486 VVSVL 490
            |:..|
Zfish   491 VILTL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	132/488 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	140/502 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	139/501 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690