DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	144/550 - (26%)
Similarity:	244/550 - (44%)	Gaps:	86/550 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPH 70
            |:|||||  ||:.|  |.....:  :.||... ||.:|.:...:|.|..||||     ||.:.|.
  Rat     9 GLAGLLL--LLYAL--PWAEGGK--VLVFPME-GSHWLSMRDVVRELHARGHQ-----AVVLAPE 61

  Fly    71 IEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPG-------VQELL 128
            :.    :.:.:.|.       |...|....:|...|..:...|. |.|.|...       ..|:|
  Rat    62 VT----VHIKEEDF-------FTLQTYPVPYTRQGFRQQMMRNI-KVVFETGNYVKTFLETSEIL 114

  Fly   129 RNASAKYSLIILEASHNDALYGFSQHFNA---------PLLG----VAAYGSSWNIDFL------ 174
            :|.|.......:...||.:|.   ||.|:         |::.    :|.|.....:.||
  Rat   115 KNISTVLLRSCMNLLHNGSLL---QHLNSSSFDMVLTDPVIPCGAVLAKYLGIPTVFFLRYIPCG 176

  Fly   175 VGNSA-----PSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGAT 234
            :.:.|     ||.|.|......:..:..:::..|::|....:.:..|.:         ..:....
  Rat   177 IDSEATQCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLALKYICHFSF---------TRYESLA 232

  Fly   235 TSIHDLRRRFSLVLINQH---------FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD- 289
            :.:  |:|..|||.:..|         |.....|..:||:|.:.|::...|. ||..|.:..::
  Rat   233 SEL--LQREVSLVEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIKK-PLSQEFEAYVNA 294

  Fly   290 EAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRA 354
            ..|||::.||:|..:.:  :|......:::|..::.|.|:|:.......|.::|.....|.||..
  Rat   295 SGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQND 357

  Fly   355 ILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIV 419
            :|.||..:.||||:|...:.|.:...||::.:|||.||..|.||||..|....|:...:..|::.
  Rat   358 LLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLE 422

  Fly   420 LAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNV 484
            .|::.::.|.|||.|...||....|:|:..:|.|::|.||::|||||.|:|.|..:::..||:::
  Rat   423 NALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSL 487

  Fly   485 DVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            ||:..|...:    :.|:|:.:|..:...|
  Rat   488 DVIGFLLAIV----LTVVFIVYKSCAYGCR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	119/479 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	130/508 (26%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	133/528 (25%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	79/252 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790