DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	530	Identity:	143/530 - (26%)
Similarity:	250/530 - (47%)	Gaps:	68/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVL-LFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI----------- 62
            |.:|:: |||.||    :...||.|  ...||.:|.:...::.|..:||.:.:|
Zfish    13 LWITIIPLFGFLC----DGGKILVV--PLEGSHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEK 71

  Fly    63 ----SAVTIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLTKW--TEAQFLSEYF--YNCSKFVL 119
                :::|| |..:|:....|.  ||:.|::   .::...:.|  |...|.....  |..:|.|.
Zfish    72 SDYYNSITI-PQSKGMDEEFVD--DMISKVI---NHERGKSSWLSTVKLFFDSVIDNYEMTKMVC 130

  Fly   120 EDP----GVQELLRNASAK-YSLIILEASHNDALYG----FSQHFNAPLLGVAAYGSSW--NID- 172
            :..    ..:|:|:....| |.|::     .|.::|    .:.....|::    |...|  .:|
Zfish   131 DITTSIFESEEILKTLQEKQYDLML-----TDPVWGMGIILAHKLKLPMV----YNVRWTTTVDG 186

  Fly   173 -FLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLI-YITEERLVERFIYLPRQIDLYKQHFPGATT 235
             |.:..| |..|.|::..|.|..::..::..|:| |.|.:....|| .||:...:..::| ....
Zfish   187 HFNIAPS-PMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRF-SLPQYQAICDKYF-DPPV 248

  Fly   236 SIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMH-LDEKPYPLDAELKKILDEAEHGVIYFS 299
            ..:.|.:...:.|:...|.....|..:|||:...|.. ...||.|.|.| ..:....:||||..|
Zfish   249 DFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCTPAKPLPHDLE-DFMQSSGDHGVIVMS 312

  Fly   300 MGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLF 364
            :|..:  ..||..:.|.::.|||:|.|:|||:....:......|.....|.||:.:|.||..|:|
Zfish   313 LGTFI--SALPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVF 375

  Fly   365 ITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNA 429
            :.|.|...:.|::::.||::.||.|:||:.|..|::..|.|:.:....|..:.:..||::::.|.
Zfish   376 VAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNP 440

  Fly   430 SYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRI 494
            ||:...:.|||...|:|:..:|:||:|.|:::|||||.|:|....:|....|::|||.      :
Zfish   441 SYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVA------V 499

  Fly   495 GLSAIIVIFL 504
            .|.|:::||:
Zfish   500 TLIAVVLIFI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	122/472 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	133/500 (27%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	136/511 (27%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	80/248 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690