DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	530	Identity:	143/530 - (26%)
Similarity:	247/530 - (46%)	Gaps:	80/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLI------------- 62
            |.|.||..|  |...||:.|| ||... ||.::.:...::.|..|||:|::|
Zfish    10 LWTSLLLSL--PSGYNADKIL-VFPID-GSHWVNMEVLVKKLQSRGHELSVIRLEDSWFIKGNSP 70

  Fly    63 --SAVTIMPHIEGVHHIRVPKLDMLMKILLDFE-YDTDLTKWTEAQF---LSEYFYNCSKFV--- 118
              |::|:                .|.|..:|.: ::|.:.|..:|:.   :.......|:|:
Zfish    71 YYSSITV----------------TLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEFIGIL 119

  Fly   119 --------------LEDPGVQELLRNASAKYSLIILEASHNDALYG---FSQHFNAPLLGVAAYG 166
                          ||:..:...::  .|.|.|::.:    .|:.|   .:.:.:.|::    |.
Zfish   120 KVGHGANIAMLTSMLENKVLMSQIK--MANYDLMLTD----PAMPGGVILAHYLHLPMV----YN 174

  Fly   167 SSWNIDFLVGN----SAPSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYK 227
            ..| :.|..|:    .:|..:.|:...|.|..:.|:|:..|.::.....:.||::.:|....|..
Zfish   175 VRW-MSFGEGHFSIAPSPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPMYTSLLL 238

  Fly   228 QHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHL-DEKPYPLDAELKKILDEA 291
            .|||.. |.:..::|...|.|:...|.....|.::||:|.:.|... ..||.|.|.| :.:....
Zfish   239 NHFPPG-TDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQCRPAKPLPADLE-EFMQSSG 301

  Fly   292 EHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAIL 356
            :|||:..|:|..:..  ||..:..:::.||||:.|:|||:...........|.....|.||..:|
Zfish   302 DHGVVVMSLGTLIAG--LPKEVMEAIASAFAQIPQKVIWRFIGQRPSTLGNNTLLIQWLPQNDLL 364

  Fly   357 NHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLA 421
            .||..:.|:.|.|...|.|::::.||:|.:||.:||..|..|::..|.||.||.......|.::|
Zfish   365 GHPKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARMLDAATCSTKEFLVA 429

  Fly   422 IEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDV 486
            :.|::.|.:|::|.:.||....|:|:..:|.|::|.|::||:|||.|:|.....:|...||.:||
Zfish   430 LTDILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEAYNVSEFSYYCLDV 494

  Fly   487 VS-VLFGRIG 495
            |: |||..:|
Zfish   495 VALVLFMLLG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	122/482 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	131/502 (26%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	143/530 (27%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	135/513 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690