DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	520	Identity:	136/520 - (26%)
Similarity:	259/520 - (49%)	Gaps:	45/520 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLIS---AVTIMPHIE 72
            :|.:|:|.|...::..:.|:  |...|.||.:|.|...|..||||.|.:|:::   .:.|...::
Mouse     5 VLQLLIFHLTLAEIVLSGNV--VVWPTDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLD 67

  Fly    73 G-VHHIRVP------KLDMLMKILLDFEYD---TDLTKWT---EAQFLSEYFYNCSK----FVLE 120
            . ::...:|      |:|.:::.::....|   |.||.||   |...|...||..:|    .||.
Mouse    68 AFINFEEIPVSYTKSKIDEIIEHMIALWLDHRPTPLTMWTFYKELGNLLATFYTTNKQMCDGVLN 132

  Fly   121 DPGVQELLRNASAKYSLIILEASHNDALYG--FSQHFNAPLLGVAAYGSSWNIDFLVGN-SAPSV 182
            :|.|.|.|:...  :.:::.:..   .:.|  .:.....|.:....:..::.::...|. .||..
Mouse   133 NPTVMERLQKGG--FDVLLADPV---TMCGELVALKLGIPFVYTLRFSPAFTVERHCGKIPAPIS 192

  Fly   183 YEPMSALGYTSGLNLIEKWHNLI-YITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSL 246
            |.|.:....|..::..|:..|:| |..::.:.:.:.   .:.:.|.....|..|::.:...:..:
Mouse   193 YVPAALSELTDQMSFGERVKNIISYSLQDYIFKTYW---GEWNSYYSKVLGRPTTLCETMGKAEI 254

  Fly   247 VLINQHFTMGRVRSNVPNIVEVAGMHLDEKP-YPLDAELKKILD-EAEHGVIYFSMGLQLLDHWL 309
            .|:..::.....|..:||...|.|:|.  || .||..|:::.:. ..|||::.||:|..:.:  |
Mouse   255 WLMRTYWDFEFPRPYLPNFEFVGGLHC--KPAKPLPKEMEEFVQTSGEHGIVVFSLGSMVKN--L 315

  Fly   310 PPGMRASMSDAFAQLKQQVIW--KTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLS 372
            .......::.|.||:.|:|:|  |...|:.:..:..:|  .|.||..:|.||..:.||||.|...
Mouse   316 TDEKANLIASALAQIPQKVLWRYKGKIPDTLGSNTRLF--DWIPQNDLLGHPKTRAFITHGGTNG 378

  Fly   373 LIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARD 437
            :.|::::.:|::.:|:|.||..|...|:..|.|.:::...:...:::.|:..::...|||.||..
Mouse   379 IYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMR 443

  Fly   438 LSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVI 502
            ||:..||||:..:|.|::|.|:::|||||.|:|:|..::|..||:::||:..|...:. |||:::
Mouse   444 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACVA-SAILLV 507

Fly 503 502
Mouse 508 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	117/466 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	129/492 (26%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	132/503 (26%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	73/225 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790