Protein Alignment Ugt303A1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 138/540 - (25%)
• Similarity: 240/540 - (44%)
• Gaps: 64/540 - (11%)

  Fly     5 PGIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMP 69
            |.:.||||.|     |.|.:::|..||.:  ...||.:|.:...::.|.||||::.:::.
Human    10 PLVLGLLLCV-----LGPVVSHAGKILLI--PVDGSHWLSMLGAIQQLQQRGHEIVVLAP----- 62

  Fly    70 HIEGVHHIRVPKLDMLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLE-DPGVQELLRNAS- 132
              :...:||......|....:.|:.:.          :.|.|.:....|.| |..:|.:::...
Human    63 --DASLYIRDGAFYTLKTYPVPFQRED----------VKESFVSLGHNVFENDSFLQRVIKTYKK 115

  Fly   133 -AKYSLIILEAS----HNDALY------GFSQHFNAPLLG----VAAYGSSWNIDFLVGNSA--- 179
             .|.|.::|...    ||..|.      .|......|.|.    ||.|.|...:.||.....
Human   116 IKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE 180

  Fly   180 --------PSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTS 236
                    |..|.|.....::..:..:::..|::....:..:...:|.|  .......|.....:
Human   181 FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSP--YATLASEFLQREVT 243

  Fly   237 IHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMH-LDEKPYPLDAELKKILD-EAEHGVIYFS 299
            :.||....|:.|....|.....|..:||:|.|.|:: |.:.  ||..|.:..:: ..|||::.||
Human   244 VQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQN--PLSQEFEAYINASGEHGIVVFS 306

  Fly   300 MGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLF 364
            :|..:.:  :|.....:::||..::.|.|:|:.......|.:.|.....|.||..:|.||..:.|
Human   307 LGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAF 369

  Fly   365 ITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNA 429
            |||||...:.||:...||::.:|||.||..|.||||..|....|:...:..:::..|::.::.:.
Human   370 ITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDK 434

  Fly   430 SYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRI 494
            |||.|...||....|:|:..:|.|::|.|:::|||||.|:|.|..:::..||:::||:..|...:
Human   435 SYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV 499

  Fly   495 GLSAIIVIFLGWKLVSLATR 514
                :.|.|:.:|..:...|
Human   500 ----LTVAFITFKCCAYGYR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	115/468 (25%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	129/517 (25%)