DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	539	Identity:	143/539 - (26%)
Similarity:	238/539 - (44%)	Gaps:	69/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVH 75
            |.|.||..|.......:..:|.|  .|.||.:|.:...||.|..||||     ||.:.|.:.  .
Human    12 LATGLLLLLSVQPWAESGKVLVV--PTDGSPWLSMREALRELHARGHQ-----AVVLTPEVN--M 67

  Fly    76 HIRVPKLDMLMKILLDFEYDTDLTKWTEAQF------LSEYFYNCSKFVLEDPGVQELLRNASAK 134
            ||:..|.         |........||:.:|      .::.|:.....:........::.|.|..
Human    68 HIKEEKF---------FTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLA 123

  Fly   135 YSLIILEASHNDALYGFSQHFNAPLLGV-------------AAYGS-----SW-----NIDFLVG 176
            .....:|..||:||.   :|.||....|             |.|.|     .|     ::|| .|
Human   124 LHRCCVELLHNEALI---RHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDF-KG 184

  Fly   177 NSA--PSVYEPMSALGYTSGLNLIEKWHNLIY-ITEERLVERFI--YLPRQIDLYKQHFPGATTS 236
            ...  ||.|.|......:..:..:::..|::| :....:...|.  |.....:|:::.     .|
Human   185 TQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQRE-----VS 244

  Fly   237 IHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVIYFSM 300
            :.||....|:.|....|.|...|..:||:|.:.|::. ....||..|.:..:: ..|||::.||:
Human   245 VVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINC-ANGKPLSQEFEAYINASGEHGIVVFSL 308

  Fly   301 GLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFI 365
            |..:.:  :|.....:::||..::.|.|:|:.......|.:.|.....|.||..:|.||..:.||
Human   309 GSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFI 371

  Fly   366 THAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNAS 430
            ||||...:.||:...||::.:|||.||..|.||||..|....|:...:..:::..|::.::.:.|
Human   372 THAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKS 436

  Fly   431 YKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIG 495
            ||.|...||....|:|:..:|.|::|.|:::|||||.|:|.|..:::..||:::||:..|...:
Human   437 YKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV- 500

  Fly   496 LSAIIVIFLGWKLVSLATR 514
               :.|.|:.:|..:...|
Human   501 ---LTVAFITFKCCAYGYR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	123/473 (26%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	133/502 (26%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	138/522 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690