DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303A1 and UGT1A9

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_066307.1	Gene:	UGT1A9 / 54600	HGNCID:	12541	Length:	530	Species:	Homo sapiens

Alignment Length:	520	Identity:	134/520 - (25%)
Similarity:	235/520 - (45%)	Gaps:	86/520 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIE---GVHHIRVPKLDMLMKILLDFEYDTDLT- 99
            ||.:..:...:..|:.|||::     |.:||.:.   |      ..|:..:|     .|.|..|
Human    35 GSHWFTMRSVVEKLILRGHEV-----VVVMPEVSWQLG------RSLNCTVK-----TYSTSYTL 83

  Fly   100 -------------KWTEAQFLSEY--------------FYNCSKFVLEDPGVQELLRNASAKYSL 137
                         :| :||..|.|              |.|| :.:.:|..:.|.|:.:|  :..
Human    84 EDLDREFKAFAHAQW-KAQVRSIYSLLMGSYNDIFDLFFSNC-RSLFKDKKLVEYLKESS--FDA 144

  Fly   138 IILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVG-----------NSAPSVYEPMSALGY 191
            :.|:...|..|.            ||.|.|..::.|..|           ..||..|.|...||:
Human   145 VFLDPFDNCGLI------------VAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGF 197

  Fly   192 TSGLNLIEKWHN-LIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTM 255
            :..:...|:..| ::::.|..|..||  ....:::..:......|. :||....|:.|:...|.:
Human   198 SDAMTFKERVRNHIMHLEEHLLCHRF--FKNALEIASEILQTPVTE-YDLYSHTSIWLLRTDFVL 259

  Fly   256 GRVRSNVPNIVEVAGMHLDE-KPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSD 319
            ...:..:||::.:.|::..: ||.|::.| ..|....|||::.||:|..:.:  :|.....:::|
Human   260 DYPKPVMPNMIFIGGINCHQGKPLPMEFE-AYINASGEHGIVVFSLGSMVSE--IPEKKAMAIAD 321

  Fly   320 AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLL 384
            |..::.|.|:|:.......|.:.|.....|.||..:|.||..:.||||||...:.||:...||::
Human   322 ALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMV 386

  Fly   385 CIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSA 449
            .:|||.||..|.||||..|....|:...:..:::..|::.::.:.|||.|...||....|:|:..
Human   387 MMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEP 451

  Fly   450 MDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            :|.|::|.|:::|||||.|:|.|..:::..||:::||:..|...:    :.|.|:.:|..:...|
Human   452 LDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV----LTVAFITFKCCAYGYR 512

Fly 515 514
Human 513 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	119/469 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	132/511 (26%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	134/520 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690