DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT1A5

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_061951.1	Gene:	UGT1A5 / 54579	HGNCID:	12537	Length:	534	Species:	Homo sapiens

Alignment Length:	542	Identity:	138/542 - (25%)
Similarity:	241/542 - (44%)	Gaps:	75/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVH 75
            |.|.||..|.......:..:|.|  .|.||.:|.:...||:|..||||:.:::.
Human    12 LATGLLLLLSVQPWAESGKVLVV--PTDGSHWLSMREALRDLHARGHQVVVLTL----------- 63

  Fly    76 HIRVPKLDMLMKILLDFEYDTDLTKWTEAQF------LSEYFYNCSKFVLEDPGVQELLRNASAK 134
                 :::|.:|....|...|....||:.:|      .::.|:.....:::......::.|.|..
Human    64 -----EVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLI 123

  Fly   135 YSLIILEASHNDALYGFSQHFNAPLLGV-------------AAYGSSWNIDFL---------VGN 177
            .....:|..||:||.   :|.:|....|             |.|.|...:.||         .|.
Human   124 IHRSCVELLHNEALI---RHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGT 185

  Fly   178 SA--PSVYEPMSALGYTSGLNLIEKWHNLIYITEERLVERFI-------YLPRQIDLYKQHFPGA 233
            ..  ||.|.|......:..:..:::..|::|    .|...::       |.....:|:::.
Human   186 QCPNPSSYIPRLLTTNSDHMTFLQRVKNMLY----PLALSYLCHAVSAPYASLASELFQRE---- 242

  Fly   234 TTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVIY 297
             .|:.||....|:.|....|.|...|..:||:|.:.|::. ....||..|.:..:: ..|||::.
Human   243 -VSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINC-ANGKPLSQEFEAYINASGEHGIVV 305

  Fly   298 FSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVK 362
            ||:|..:.:  :|.....:::||..::.|.|:|:.......|.:.|.....|.||..:|.||..:
Human   306 FSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTR 368

  Fly   363 LFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVY 427
            .||||||...:.||:...||::.:|||.||..|.||||..|....|:...:..:::..|::.::.
Human   369 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 433

  Fly   428 NASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFG 492
            :.|||.|...||....|:|:..:|.|::|.|:::|||||.|:|.|..:::..||:::||:..|..
Human   434 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 498

  Fly   493 RIGLSAIIVIFLGWKLVSLATR 514
            .:    :.|.|:.:|..:...|
Human   499 VV----LTVAFITFKCCAYGYR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	118/476 (25%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	128/505 (25%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	133/525 (25%)
UGT1A5	NP_061951.1	egt	<262..508	CDD:223071	79/252 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.790