DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	537	Identity:	132/537 - (24%)
Similarity:	233/537 - (43%)	Gaps:	119/537 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHIRVPKLDMLMK-------ILLDFEYDT 96
            ||.:|.:...:..|..|||::.::                ||::::|:|       .:....||.
Human    36 GSHWLSMKDIVEVLSDRGHEIVVV----------------VPEVNLLLKESKYYTRKIYPVPYDQ 84

  Fly    97 DLTK----------WTEAQFLSE--------------YFYNCSKFVLEDPGVQELLRNASAKYSL 137
            :..|          :.|..||:.              ||.||          |.||::   :.:|
Human    85 EELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINC----------QSLLQD---RDTL 136

  Fly   138 IILEASHNDALYGFSQHFNAPLL--GV--AAY----------GSSWNIDFLVGNSA-PSVYEPMS 187
            ...:.|..|||      |..|.|  ||  |.|          |...:::.....|. |..|.|..
Human   137 NFFKESKFDAL------FTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRC 195

  Fly   188 ALGYTSGLNLIEKWHNLIYITEERLVERFIY--------------LPRQIDLYKQHFPGATTSIH 238
            ...::..:...::..|.:.    .|:|.:::              |.|.:|            |.
Human   196 YTKFSDHMTFSQRVANFLV----NLLEPYLFYCLFSKYEELASAVLKRDVD------------II 244

  Fly   239 DLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILD-EAEHGVIYFSMGL 302
            .|.::.|:.|:...|.:...|..:||:|.:.|::. :|...|..|.:..:: ..|||::.||:|.
Human   245 TLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINC-KKRKDLSQEFEAYINASGEHGIVVFSLGS 308

  Fly   303 QLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITH 367
            .:.:  :|.....:::||..::.|.|:|:.......|.:.|.....|.||..:|.||..:.||||
Human   309 MVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 371

  Fly   368 AGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYK 432
            ||...:.||:...||::.:|||.||..|.||||..|....|:...:..:::..|::.::.:.|||
Human   372 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 436

  Fly   433 RNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLS 497
            .|...||....|:|:..:|.|::|.|:::|||||.|:|.|..:::..||:::||:..|...:
Human   437 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV--- 498

  Fly   498 AIIVIFLGWKLVSLATR 514
             :.|.|:.:|..:...|
Human   499 -LTVAFITFKCCAYGYR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	117/486 (24%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	130/528 (25%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	130/527 (25%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	132/537 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690