Protein Alignment Ugt303A1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 139/551 - (25%)
• Similarity: 246/551 - (44%)
• Gaps: 85/551 - (15%)

  Fly     6 GIAGLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPH 70
            |..|||...:...|.| ....|..:|.|  ...||.:..:...:..|:.|||::     |.:||.
Human     5 GWTGLLPLYVCLLLTC-GFAKAGKLLVV--PMDGSHWFTMQSVVEKLILRGHEV-----VVVMPE 61

  Fly    71 IE---GVHHIRVPKLDMLMKILLDFEYDTDLT--------------KWT------------EAQF 106
            :.   |      ..|:..:|     .|.|..|              :||            .:..
Human    62 VSWQLG------RSLNCTVK-----TYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNG 115

  Fly   107 LSEYFYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNI 171
            :.:.|::..:.:..|..:.|.|:.            |..||:  |...|:|..|.||.|.|..::
Human   116 IFDLFFSNCRSLFNDRKLVEYLKE------------SCFDAV--FLDPFDACGLIVAKYFSLPSV 166

  Fly   172 DFLVG-----------NSAPSVYEPMSALGYTSGLNLIEK-WHNLIYITEERLVERFIYLPRQID 224
            .|..|           ..||..|.|...||::..:...|: |::::::.|......|  ....::
Human   167 VFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYF--FKNVLE 229

  Fly   225 LYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVRSNVPNIVEVAGMHLDE-KPYPLDAELKKIL 288
            :..:......|: :||....|:.|:...|.:...:..:||::.:.|::..: ||.|::.| ..|.
Human   230 IASEILQTPVTA-YDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFE-AYIN 292

  Fly   289 DEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQR 353
            ...|||::.||:|..:.:  :|.....:::||..::.|.|:|:.......|.:.|.....|.||.
Human   293 ASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQN 355

  Fly   354 AILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEI 418
            .:|.||..:.||||||...:.||:...||::.:|||.||..|.||||..|....|:...:..:::
Human   356 DLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 420

  Fly   419 VLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYN 483
            ..|::.::.:.|||.|...||....|:|:..:|.|::|.|:::|||||.|:|.|..:::..||::
Human   421 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHS 485

  Fly   484 VDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            :||:..|...:    :.|.|:.:|..:...|
Human   486 LDVIGFLLAVV----LTVAFITFKCCAYGYR 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	118/480 (25%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	132/529 (25%)