Protein Alignment Ugt303A1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_652621.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 131/516 - (25%)
• Similarity: 242/516 - (46%)
• Gaps: 78/516 - (15%)

  Fly    39 GSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLT---- 99
            ||.:..:...:..|:.|||::     |.:||.:..       :|:..:...:. .|.|..|
Human    35 GSHWFTMQSVVEKLILRGHEV-----VVVMPEVSW-------QLERSLNCTVK-TYSTSYTLEDQ 86

  Fly   100 ----------KW-TEAQ------------FLSEYFYNCSKFVLEDPGVQELLRNASAKYSLIILE 141
                      :| .:||            ||..:|.:| :.:..|..:.|.|:.:|.
Human    87 NREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHC-RSLFNDRKLVEYLKESSF-------- 142

  Fly   142 ASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVG-----------NSAPSVYEPMSALGYTSGL 195
                ||:  |...|:...|.||.|.|..::.|..|           ..||..|.|...||::..:
Human   143 ----DAV--FLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAM 201

  Fly   196 NLIEK-WHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVR 259
            ...|: |:::::: |:.|..:::: ...:::..:......|: :||....|:.|:...|.:...:
Human   202 TFKERVWNHIVHL-EDHLFCQYLF-RNALEIASEILQTPVTA-YDLYSHTSIWLLRTDFVLDYPK 263

  Fly   260 SNVPNIVEVAGMHLDE-KPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQ 323
            ..:||::.:.|::..: ||.|::.| ..|....|||::.||:|..:.:  :|.....:::||..:
Human   264 PVMPNMIFIGGINCHQGKPLPMEFE-AYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGK 325

  Fly   324 LKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPL 388
            :.|.|:|:.......|.:.|.....|.||..:|.||..:.||||||...:.||:...||::.:||
Human   326 IPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPL 390

  Fly   389 FYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTA 453
            |.||..|.||||..|....|:...:..:::..|::.::.:.|||.|...||....|:|:..:|.|
Human   391 FGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLA 455

  Fly   454 IWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            ::|.|:::|||||.|:|.|..:::..||:::||:..|...:    :.|.|:.:|..:...|
Human   456 VFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV----LTVAFITFKCCAYGYR 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_652621.1	Glycosyltransferase_GTB-type	26..465	CDD:471961	116/465 (25%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	131/516 (25%)