Protein Alignment Ugt303A1 and UGT1A10

DIOPT Version :9

• Sequence 1: NP_001262470.1
• Gene: Ugt303A1 / 53503
• FlyBaseID: FBgn0040252
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 131/516 - (25%)
• Similarity: 242/516 - (46%)
• Gaps: 78/516 - (15%)

  Fly    39 GSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVHHIRVPKLDMLMKILLDFEYDTDLT---- 99
            ||.:..:...:..|:.|||::     |.:||.:..       :|:..:...:. .|.|..|
Human    35 GSHWFTMQSVVEKLILRGHEV-----VVVMPEVSW-------QLERSLNCTVK-TYSTSYTLEDQ 86

  Fly   100 ----------KW-TEAQ------------FLSEYFYNCSKFVLEDPGVQELLRNASAKYSLIILE 141
                      :| .:||            ||..:|.:| :.:..|..:.|.|:.:|.
Human    87 NREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHC-RSLFNDRKLVEYLKESSF-------- 142

  Fly   142 ASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVG-----------NSAPSVYEPMSALGYTSGL 195
                ||:  |...|:...|.||.|.|..::.|..|           ..||..|.|...||::..:
Human   143 ----DAV--FLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLGFSDAM 201

  Fly   196 NLIEK-WHNLIYITEERLVERFIYLPRQIDLYKQHFPGATTSIHDLRRRFSLVLINQHFTMGRVR 259
            ...|: |:::::: |:.|..:::: ...:::..:......|: :||....|:.|:...|.:...:
Human   202 TFKERVWNHIVHL-EDHLFCQYLF-RNALEIASEILQTPVTA-YDLYSHTSIWLLRTDFVLDYPK 263

  Fly   260 SNVPNIVEVAGMHLDE-KPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQ 323
            ..:||::.:.|::..: ||.|::.| ..|....|||::.||:|..:.:  :|.....:::||..:
Human   264 PVMPNMIFIGGINCHQGKPLPMEFE-AYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADALGK 325

  Fly   324 LKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPL 388
            :.|.|:|:.......|.:.|.....|.||..:|.||..:.||||||...:.||:...||::.:||
Human   326 IPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPL 390

  Fly   389 FYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTA 453
            |.||..|.||||..|....|:...:..:::..|::.::.:.|||.|...||....|:|:..:|.|
Human   391 FGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLA 455

  Fly   454 IWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIFLGWKLVSLATR 514
            ::|.|:::|||||.|:|.|..:::..||:::||:..|...:    :.|.|:.:|..:...|
Human   456 VFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV----LTVAFITFKCCAYGYR 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	116/465 (25%)
		UDPGT	39..507	CDD:278624	129/507 (25%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	131/516 (25%)
		egt	<258..504	CDD:223071	78/252 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690