DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	154/535 - (28%)
Similarity:	252/535 - (47%)	Gaps:	40/535 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIM--PHI- 71
            |.:.||:.|      .:..|||.:|:....|..::.....|.|.:|||.:|:   |||:  |.:
  Fly    10 LQIVVLIAG------AHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTV---VTILKPPSLH 65

  Fly    72 EGVHHIRVPKLDMLMKILLDFE------YDTD-----LTKWTEAQFLSEYFYNCSKF--VLEDPG 123
            :.::||.||   |...||..|.      ..||     ::.:...:.|||.|   ||.  |::.|.
  Fly    66 KDINHILVP---MEEDILQAFNSVVGGMTKTDNSNAYVSMFRSVRQLSETF---SKMGDVMKQPL 124

  Fly   124 VQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVYEPMSA 188
            |::|..:...|:.|:::....|......:.....||: ||.......:.:|:||.....|.|..:
  Fly   125 VKDLYEHPDNKFDLVMVGYFMNCYQLALAHKLKVPLV-VALSNPPSFLGYLLGNPWEVSYVPGMS 188

  Fly   189 LGYTSG--LNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGATT--SIHDLRRRFSLVLI 249
            :....|  |....:..||:....:||. .||...|...:|::.:....|  |..||.:..||:..
  Fly   189 VSIKGGKPLGFGHRVLNLLGSMAQRLF-MFIIELRNARIYREIYGDDPTLPSYEDLHKNISLIFF 252

  Fly   250 NQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGM 313
            ..| .:.|.:|.|||.::|:.|:.:.|:|..|...:::.|.||.:|.|..|:|..|.:..|....
  Fly   253 ASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNGAILLSLGSNLKEDHLKSST 317

  Fly   314 RASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESV 377
            ...|.:..::|:|:|||| .|...:..:|.|:....|.||..:|.|||:.|||||||...|.|:.
  Fly   318 VQKMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAHPNITLFITHAGKGGLTEAQ 382

  Fly   378 HYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRF 442
            ::..|:|.:|:|.||..|...|...|...|.....|..|..:..|.:::.|..|....:..|..:
  Fly   383 YHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPKYATAVKSFSTLY 447

  Fly   443 HDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRI-GLSAIIVIFLGW 506
            .|:|:|..:|.|:|.||::|:.||.|::.....||.:...|:||.:|:.|.| .|..|..:..|.
  Fly   448 RDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIVALCFITKLLFGL 512

  Fly   507 KLVSLATRHLEYRLN 521
            .:..|.....:.::|
  Fly   513 VVGKLRKNSRKAKVN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	134/460 (29%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	144/490 (29%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	152/527 (29%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	141/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445798
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950