DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303A1 and Ugt37C1

DIOPT Version :9

Sequence 1:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	130/490 - (26%)
Similarity:	233/490 - (47%)	Gaps:	49/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LVQRGHQLTLISAVTIMPHIEGVHHIRVP---------------------KLDMLMKILLDFEYD 95
            |.:.||.:|::|.:......:.:|.|.||                     .:...|.:||:   .
  Fly     7 LAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNIITTMYLLLN---G 68

  Fly    96 TDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLL 160
            .|:...::|.            :|:||..|.:.   ..|:.|:||.:..||...|.:.....|::
  Fly    69 LDVMVTSQAD------------LLKDPRFQRVF---ETKFDLMILGSFFNDFQLGVAGKLKVPVI 118

  Fly   161 GVAAYGSSWNIDFLVGNSAPSVYEPMSALGYTSGLNLIEKWHNLI-YITEERLVERFIYLPRQID 224
            ......|:..||..|.|.:...|.|..:...|:.::..::..||: ::..:.|..||.|...:|
  Fly   119 VDWMIPSNTMIDEFVANPSEVSYVPNESTFATTPMSFFKRAENLVKHVILKYLTIRFNYKFNRI- 182

  Fly   225 LYKQHFPGA-TTSIHDLRRRFSLVLINQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKI 287
             |.:.|... ..::.::::..|:|.:..| .:.|.:|..||.|:||.|:.:.|:|.||..::::.
  Fly   183 -YNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQPDPLPQDIEQF 246

  Fly   288 LDEAEHGVIYFSMGLQLLDHWLPPGMRASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTWFP 351
            ::.:..|.|:.|.|..:..:.:.|.:...|....:.|||.|||| .|.......:.|:|.:.|.|
  Fly   247 MENSSQGAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKWEDLENTPGNASNIFYKDWLP 311

  Fly   352 QRAILNHPNVKLFITHAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRD 416
            |..||.|||.|||:||||..|:.||.::.||::.:|:|.|...|...|...|....||.:.:..|
  Fly   312 QDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSGYGVSLDLQTITED 376

  Fly   417 EIVLAIEDLVYNASYKRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQY 481
            ....||.:::.|..|.:..|..|..:.|:|::...:.::|.:|:|||.||.:::.....|..::.
  Fly   377 TFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPNLQSPAVHMGFVEL 441

  Fly   482 YNVD----VVSVLFGRIGLSAIIVIFLGWKLVSLA 512
            :|:|    |:::|...:.|:.:.|.||..||:..|
  Fly   442 HNLDIYALVLAILIFLVFLTRLTVKFLFSKLLGKA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	116/437 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	127/483 (26%)
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	130/490 (27%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	118/445 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445742
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850